Blar i tittel Doktorgradsavhandlinger (Helsefak)
Viser treff 252-271 av 697
-
Gene expression in blood and cancer risk factors – Investigating associations of blood gene expression with Smoking, BMI, and Menopause in the Norwegian Women and Cancer (NOWAC) postgenome cohort
(Doctoral thesis; Doktorgradsavhandling, 2023-10-24)<p><i>Background:</i> Linking blood gene expression and common cancer risk factors represents an intriguing approach for gaining valuable biological insights. Smoking and obesity are important modifiable cancer risk factors. Menopause is also an important factor due to its impact on cancer risk. Still, there is limited or no research evaluating associations of blood gene expression profiles with ... -
Gene expression profile of normal and compromised placentas
(Doctoral thesis; Doktorgradsavhandling, 2009-06-26)<b>Objective</b> <br>Placenta has an important function of sustaining life in utero. Role of placental gene expression in the physiology of parturition and pathogenesis of pregnancy disorders are poorly understood. The aims of this thesis were to: <br>1. Investigate the effect of labor on global gene expression profile of normal placentas <br>2. Compare placental gene expression profile of ... -
General practitioner hospitals : use and usefulness : a study from Finnmark County in North Norway.
(Doctoral thesis; Doktorgradsavhandling, 1998) -
General Practitioners’ Decisions to Refer Patients to Secondary Care – Referral Rates, Reasons for Referral and Expected Medical Benefit of the Referrals
(Doctoral thesis; Doktorgradsavhandling, 2015-04-09)Summary Background The referral rates of general practitioners (GPs) are an important determinant of secondary care utilisation. The considerable variation in these rates between GPs cannot be explained by patient morbidity alone. Other factors, like health care organisation, GP characteristics and patient preference play an important role, but the extent of their mutual contributions is not ... -
A genetic spectrum approach to affective and schizophrenic disorders : a twin- and family study
(Doctoral thesis; Doktorgradsavhandling, 2009-09-15)Over 300 eneggete- og toeggete tvillingpar rekruttert fra sykehusarkiv, og deres 1.grads slektninger (foreldre og søsken), ble intervjuet personlig og diagnostisert i henhold til moderne diagnostiske systemer (DSM-III-R) både med hensyn til symptomforstyrrelser (Akse I), og personlighetsforstyrrelser (Akse II). De ble også intervjuet angående forhold knyttet til tvillingenes fødsel og oppvekst. ... -
Genetic Susceptibility, Lifestyle, Ovarian Hormones, and Mammographic Density – key factors in breast cancer development. The Norwegian Energy Balance and Breast Cancer Aspects-I Study.
(Doctoral thesis; Doktorgradsavhandling, 2013-02-28)Breast cancer is the most frequent cancer among women worldwide. Over the last century, the prevalence of overnutrition, overweight and obesity has increased, age at menarche has dropped and age at birth of first child has risen among women in Western countries. These trends may be linked to exposure to ovarian hormones that, in turn, may affect a woman’s lifetime risk of getting breast cancer. The ... -
Genital Chlamydia trachomatis infections among adolescents in a high-incidence area in Norway: genotypes, prevalence, early sexual behaviour and testing patterns – a cross-sectional study The Finnmark High School Study (FHSS)
(Doctoral thesis; Doktorgradsavhandling, 2013-12-06)Chlamydia trachomatis is the most commonly reported curable sexually transmitted infection in Western high-income countries and can cause severe female reproductive tract morbidity. Despite extensive control efforts, chlamydia rates have increased in most countries since the mid-1990s. Young persons and especially adolescent girls have the highest infection rates. In general, girls are tested far ... -
A genome-wide study of gene expression regulation in the Gram-negative fish pathogen Aliivibrio salmonicida
(Doctoral thesis; Doktorgradsavhandling, 2011-10-04)Regulation of gene expression is essential for all bacteria to function and survive. The expression of genes into proteins is dependent on a number of steps, each of which can be subjected to regulation. In the literature much emphasis has typically been placed on transcriptional regulation, but during recent years gene regulation at the post-transcriptional level has also gained much attention. One ... -
Geographic and socioeconomic variation in the utilisation of specialist health care services in Norway – Three selected health care services
(Doctoral thesis; Doktorgradsavhandling, 2022-06-21)<p>The overall theme of this thesis is geographic and socioeconomic variation in the use of specialist health care services. Three different health care services were studied. Complete population data on individual level with high level of quality from nationwide registries (i.e., The Norwegian Patient Registry, The Cancer Registry of Norway and Statistics Norway) were used in the analysis. <p>The ... -
Glucose metabolism, genetic factors, vitamin D binding protein and directly measured free 25-hydroxyvitamin D -Results from a randomized controlled trial with high-dose vitamin D supplementation in subjects with prediabetes
(Doctoral thesis; Doktorgradsavhandling, 2016-04-21)Tidligere studier har vist en sammenheng mellom vitamin D-nivåer og type 2 diabetes, men om vitamin D kan brukes for å forebygge type 2 diabetes, har ikke vært kjent. 511 personene ble inkludert i studien og jevnt fordelt til å motta enten ukentlig høy-dose vitamin D-tilskudd eller narremedisin (placebo). Etter ett år var det ingen effekt av vitamin D-tilskudd på utviklingen av type 2 diabetes ... -
Group-based and individualized physiotherapy for persons with multiple sclerosis - A qualitative observational and interview study
(Doctoral thesis; Doktorgradsavhandling, 2019-11-11)Physiotherapy is a complex professional practice, particularly in the care for persons with multiple sclerosis (MS). Group-based organization of interventions is a common treatment approach in MS rehabilitation, regardless of limited knowledge on the nature of essential elements of such professional practices. This dissertation presents and discusses how actions and interactions affect opportunities ... -
Growing an information infrastructure for healthcare based on the development of large-scale Electronic Patient Records
(Doctoral thesis; Doktorgradsavhandling, 2018-04-04)This thesis provides empirical insights about socio-technical interdependencies affecting the making and scaling of an Information Infrastructure (II) for healthcare based on the development of large-scale Electronic Patient Records. The Ph.D. study is an interpretive case study, where the empirical data has been collected from 2012 to 2017. In most developed countries, the pressures from politicians ... -
Guanylate cyclase activators and stimulators. Potential cardiovascular therapeutics, with special focus on the right ventricle
(Doctoral thesis; Doktorgradsavhandling, 2022-09-09)<p><i>Background -</i> Soluble guanylate cyclase, sGC, is a major contributor to the signal transduction in the cardiovascular system, and dysfunction in the NO-sGC-cGMP signaling plays an important role in cardiovascular disease. This system is sensitive to a wide variety of pathological conditions spanning from substrate shortage to sGC-insensitivity to nitric oxide (NO), during pathological ... -
Harnessing Innate Immunity - Complement and TLR Inhibition in Experimental Models of Gram Positive and Polymicrobial Bacteremia and Sepsis
(Doctoral thesis; Doktorgradsavhandling, 2017-11-28)Sepsis is a syndrome of life-threatening organ malfunction caused by a dysregulated host response to infection. The complement, kallikrein/kinin, coagulation and fibrinolysis plasma cascade systems as well as the TLR system recognize and initiate the immediate responses to infection and thus play an important role in the development of sepsis. In this regard, the ubiquitous TLR co-receptor, CD14, ... -
Headache and neck or shoulderpain. An analysis of musculoskeletal problems in three comprehensive population studies in Northern Norway.
(Doctoral thesis; Doktorgradsavhandling, 1992) -
Health anxiety as a continuous construct in the general population - measuring the distribution of health anxiety and the associations with healthcare use, physical disease and cardiovascular risk factors
(Doctoral thesis; Doktorgradsavhandling, 2022-11-07)<p><i>Background:</i> Health anxiety (HA) concerns worry of disease, and has mostly been examined in people with severe HA/hypochondriasis. However, HA can be conceptualised as a continuous construct, with levels ranging from low to severe. There is little knowledge on the distribution of HA as a continuous construct in the general population, nor the association between different levels of HA and ... -
Health care professionals’ caretaking of persons with dementia who use dietary supplements
(Doctoral thesis; Doktorgradsavhandling, 2023-10-12)Persons with dementia experience progressive loss of cognitive functioning and increasing need for help with activities of daily living, including help with administering their prescribed drugs (PD). This thesis describes the use of dietary supplements (DS) (including herbs) by persons with dementia and the risk related to their use, as DS may cause adverse effects. It further describes the awareness ... -
Health education and self care in dentistry : surveys and interventions.
(Doctoral thesis; Doktorgradsavhandling, 1989) -
A healthy lifestyle index and cancer: Using a multifactor lifestyle exposure to estimate cancer incidence and survival among Norwegian women
(Doctoral thesis; Doktorgradsavhandling, 2023-08-17)<p><i>Background:</i> Cancer is the leading cause of death in Norway, and lifestyle behaviors are a major contributor to cancer risk. This thesis aimed to investigate the association between a healthy lifestyle index (HLI) and cancer incidence and survival among women in Norway. <p><i>Methods:</i> The study used data from the Norwegian Women and Cancer Study, a national prospective cohort of ... -
Hearing in rock musicians
(Doctoral thesis; Doktorgradsavhandling, 2018-12-14)Musicians are known to have an increased prevalence of hearing loss and tinnitus due to noise-induced cochlear damage. Rock music is popularly considered a major culprit in terms of excessive sound levels, but the literature on hearing in rock musicians is sparse. In this dissertation the hearing levels of a large number of rock musicians are assessed in relation to factors such as degree of exposure, ...