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dc.contributor.authorDietrichs, Erik Sveberg
dc.contributor.authorSager, Georg
dc.contributor.authorTveita, Torkjel
dc.date.accessioned2017-01-31T08:53:27Z
dc.date.available2017-01-31T08:53:27Z
dc.date.issued2016-12-05
dc.description.abstractRewarming from accidental hypothermia is often complicated by hypothermia-induced cardiac dysfunction, calling for immediate pharmacologic intervention. Studies show that although cardiac pharmacologic support is applied when rewarming these patients, a lack of updated treatment recommendations exist. Mainly due to lack of clinical and experimental data, neither of the international guidelines includes information about pharmacologic cardiac support at temperatures below 30 °C. However, core temperature of accidental hypothermia patients is often reduced below 30 °C. Few human studies exploring effects of adrenergic drugs during hypothermia have been published, and therefore prevailing information is collected from pre-clinical studies. The most prominent finding in these studies is an apparent depressive effect of adrenaline on cardiac function when used in doses which elevate cardiac output during normothermia. Also noradrenaline and isoprenaline largely lacked positive cardiac effects during hypothermia, while dopamine is a more promising drug for supporting cardiac function during rewarming. Data and information from these studies are in support of the prevailing notion; not to use adrenergic drugs at core temperatures below 30 °Cen_US
dc.descriptionThis article is distributed under the terms of the <a href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</a>, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.<a href="http://creativecommons.org/publicdomain/zero/1.0"> The Creative Commons Public Domain Dedication waiver</a> applies to the data made available in this article, unless otherwise stated. <br> This article is also available via DOI:<a href="http://dx.doi.org/10.1186/s13049-016-0339-8">10.1186/s13049-016-0339-8</a>en_US
dc.identifier.citationDietrichs ES, Sager gs, Tveita T. Altered pharmacological effects of adrenergic agonists during hypothermia. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2016;24:143:1-9en_US
dc.identifier.issn1757-7241
dc.identifier.otherFRIDAID 1409269
dc.identifier.other10.1186/s13049-016-0339-8
dc.identifier.urihttp://hdl.handle.net/10037/10240
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.journalScandinavian Journal of Trauma, Resuscitation and Emergency Medicine
dc.rights.accessRightsopenAccessen_US
dc.subjectHypothermiaen_US
dc.subjectCoolingen_US
dc.subjectRewarmingen_US
dc.subjectRearming shocken_US
dc.subjectPharmacologyen_US
dc.subjectCardiovascular dysfunctionen_US
dc.subjectAdrenergic drugsen_US
dc.subjectInotropicen_US
dc.subjectVasopressoren_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Traumatologi: 783en_US
dc.titleAltered pharmacological effects of adrenergic agonists during hypothermiaen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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