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dc.contributor.advisorPfhul, Gerit
dc.contributor.authorKaurin, Sunniva
dc.date.accessioned2017-02-02T06:33:06Z
dc.date.available2017-02-02T06:33:06Z
dc.date.issued2016-11-01
dc.description.abstractThe key objective of this study was to assess changes in the oral microbiome in relation to acute stress. Saliva samples were collected to analyze stress hormones and bacterial transcriptomic profiles. The participants underwent a socially evaluative cold pressor task (SECPT), reliably activating the HPA axis and eliciting pain and physiological responses in the participants, respectively (Skoluda et al., 2015). The level of salivary cortisol is related to the activation of the HPA axis, and serves as a reliable biomarker for stress assessment (Dickerson & Kemeny, 2004; Ivkovic, Bozovic, Racic, Popovic-Grubac & Davidovic, 2015). The transcriptome is constantly responding to environmental conditions, and stress can be a major influence. By profiling the bacterial transcriptome in relation to the stressor, we could gain information about which genes are being actively expressed. If we are able to develop a protocol for capturing correlations between changes in oral bacterial transcriptome and stress, in search of new biomarkers, it will provide the field with a novel tool in measuring stress using saliva. Furthermore, it may be used to assess individuals at risk of developing chronic stress and depression. Keywords: Gut-microbiota-brain axis, oral microbiome, transcriptomics, HPA-axisen_US
dc.identifier.urihttps://hdl.handle.net/10037/10274
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2016 The Author(s)
dc.subject.courseIDPSY-2901
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260::Klinisk psykologi: 262en_US
dc.subjectVDP::Social science: 200::Psychology: 260::Clinical psychology: 262en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260::Biologisk psykologi: 261en_US
dc.subjectVDP::Social science: 200::Psychology: 260::Biological psychology: 261en_US
dc.titleAssessment of bacteria gene expression changes in host oral microbiome during stress.A pilot studyen_US
dc.typeMaster thesisen_US
dc.typeMastergradsoppgaveen_US


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