Diet quality scores and prediction of all-cause, cardiovascular and cancer mortality in a pan-european cohort study
Permanent lenke
https://hdl.handle.net/10037/10336Dato
2016-07-13Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Lassale, Camille; Gunter, Marc J.; Romaguera, Dora; Peelen, Linda M.; van der Schouw, Yvonne T.; Beulens, Joline W.J.; Freisling, Heinz; Muller, David C.; Ferrari, Pietro; Huybrechts, Inge; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Affret, Aurélie; Overvad, Kim; Dahm, Christina C.; Olsen, Anja; Roswall, Nina; Tsilidis, Konstantinos K.; Katzke, Verena A.; Kühn, Tilman; Buijsse, Brian; Quirós, José Ramón; Sánchez-Cantalejo, Emilio; Etxezarreta, Nerea; Huerta, José María; Barricarte, Aurelio; Bonet, Catalina; Khaw, Kay-Tee; Key, Timothy J.; Trichopoulou, Antonia; Bamia, Christina; Lagiou, Pagona; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Fasanelli, Francesca; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Boer, Jolanda M.A.; Sonestedt, Emily; Nilsson, Lena Maria; Renström, Frida; Weiderpass, Elisabete; Skeie, Guri; Lund, Eiliv; Moons, Karel G.M.; Riboli, Elio; Tzoulaki, IoannaSammendrag
Scores of overall diet quality have received increasing attention in relation to disease aetiol-
ogy; however, their value in risk prediction has been little examined. The objective was to assess
and compare the association and predictive performance of 10 diet quality scores on 10-year risk of
all-cause, CVD and cancer mortality in 451,256 healthy participants to the European Prospective
Investigation into Cancer and Nutrition, followed-up for a median of 12.8y. All dietary scores
studied showed significant inverse associations with all outcomes. The range of HRs (95% CI) in the
top vs. lowest quartile of dietary scores in a composite model including non-invasive factors (age,
sex, smoking, body mass index, education, physi- cal activity and study centre) was 0.75
(0.72–0.79) to 0.88 (0.84–0.92) for all-cause, 0.76
(0.69–0.83) to 0.84 (0.76–0.92) for CVD and 0.78 (0.73–0.83) to 0.91 (0.85–0.97) for cancer
mortality. Models with dietary scores alone showed low discrimination, but composite models also
including age, sex and other non-invasive factors showed good discrimination and cali- bration,
which varied little between different diet scores examined. Mean C-statistic of full models was
0.73, 0.80 and 0.71 for all-cause, CVD and cancer mortality. Dietary scores have poor predictive
performance for 10-year mortality risk when used in isolation but display good predictive ability
in combination with other non-invasive common risk factors.
Beskrivelse
Source: doi:10.1371/journal.pone.0159025