Show simple item record

dc.contributor.authorHarms, Klaus
dc.contributor.authorLunnan, Asbjørn
dc.contributor.authorHulter, Nils
dc.contributor.authorMourier, Tobias
dc.contributor.authorVinner, Lasse
dc.contributor.authorAndam, Cheryl P
dc.contributor.authorMarttinen, Pekka
dc.contributor.authorFridholm, Helena
dc.contributor.authorHansen, Anders Johannes
dc.contributor.authorHanage, William P
dc.contributor.authorNielsen, Kaare Magne
dc.contributor.authorWillerslev, Eske
dc.contributor.authorJohnsen, Pål Jarle
dc.date.accessioned2017-02-27T12:07:51Z
dc.date.available2017-02-27T12:07:51Z
dc.date.issued2016-12-27
dc.description.abstractIn a screen for unexplained mutation events we identified a previously unrecognized mechanism generating clustered DNA polymorphisms such as microindels and cumulative SNPs. The mechanism, short-patch double illegitimate recombination (SPDIR), facilitates short single-stranded DNA molecules to invade and replace genomic DNA through two joint illegitimate recombination events. SPDIR is controlled by key components of the cellular genome maintenance machinery in the gram-negative bacterium Acinetobacter baylyi. The source DNA is primarily intragenomic but can also be acquired through horizontal gene transfer. The DNA replacements are nonreciprocal and locus independent. Bioinformatic approaches reveal occurrence of SPDIR events in the gram-positive human pathogen Streptococcus pneumoniae and in the human genome.en_US
dc.description.sponsorshipThe cancer work was supported by The Danish National Advanced Technology foundation (The GenomeDenmark platform, Grant 019-2011-2). This work was supported by The Arctic University of Norway and the Danish National Research Foundation (K.H.), the Academy of Finland Grant 251170 (to P.M.), the Finnish Centre of Excellence in Computational Inference Research Grant 259272 (to P.M.), and also by Norwegian Research Council Grant 204263/F20 (to P.J.J.).en_US
dc.descriptionSource: <a href=http://dx.doi.org/10.1073/pnas.1615819114>doi: 10.1073/pnas.1615819114</a>en_US
dc.identifier.citationHarms K, Lunnan, Hulter, Mourier, Vinner, Andam, Marttinen P, Fridholm, Hansen, Hanage, Nielsen KM, Willerslev E, Johnsen Pj. Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms. Proceedings of the National Academy of Sciences of the United States of America. 2016;113(52):15066-15071en_US
dc.identifier.cristinIDFRIDAID 1439775
dc.identifier.doi10.1073/pnas.1615819114
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttps://hdl.handle.net/10037/10367
dc.language.isoengen_US
dc.publisherNational Academy of Sciencesen_US
dc.relation.journalProceedings of the National Academy of Sciences of the United States of America
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.titleSubstitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphismsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record