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dc.contributor.authorLaake, Ida
dc.contributor.authorLarsen, Inger Kristin
dc.contributor.authorSelmer, Randi
dc.contributor.authorThune, Inger
dc.contributor.authorVeierød, Marit Bragelien
dc.date.accessioned2017-02-28T12:51:55Z
dc.date.available2017-02-28T12:51:55Z
dc.date.issued2016-07-07
dc.description.abstractBackground:<br> Whether excess body weight influences colorectal cancer (CRC) survival is unclear. We studied pre-diagnostic body mass index (BMI) and weight change in relation to CRC-specific mortality among incident CRC cases within a large, Norwegian cohort.<br> Methods:<br> Participants’ weight was measured at health examinations up to three times between 1974 and 1988. CRC cases were identified through linkage with the Norwegian Cancer Registry. In total, 1336 men and 1180 women with a weight measurement >3 years prior to diagnosis were included in analyses. Hazard ratios (HRs) and confidence intervals (CIs) were estimated with Cox regression.<br> Results:<br> During a mean follow-up of 5.8 years, 507 men and 432 women died from CRC. Obesity (BMI ≥30 kg/m2) was associated with higher CRC-specific mortality than normal weight (BMI 18.5–25 kg/m2) in men with proximal colon cancer, HR = 1.85 (95 % CI 1.08–3.16) and in women with rectal cancer, HR = 1.93 (95 % CI 1.13–3.30). Weight gain was associated with higher CRC-specific mortality in women with CRC, colon cancer, and distal colon cancer, HRs per 5 kg weight gain were 1.18 (95 % CI 1.01–1.37), 1.22 (95 % CI 1.02–1.45), and 1.40 (95 % CI 1.01–1.95), respectively. Weight gain was not significantly associated with survival in men.<br> Conclusions:<br> Maintaining a healthy weight may benefit CRC survival, at least in women.<br> Keywords:<br> Colorectal cancer Survival Body mass index Weight change Cohort studyen_US
dc.descriptionSource: <a href=http://dx.doi.org/10.1186/s12885-016-2445-4>doi: 10.1186/s12885-016-2445-4</a>en_US
dc.identifier.citationLaake I et al. Pre-diagnostic body mass index and weight change in relation to colorectal cancer survival among incident cases from a population-based cohort study. BMC Cancer. 2016;16en_US
dc.identifier.cristinIDFRIDAID 1375543
dc.identifier.doi10.1186/s12885-016-2445-4
dc.identifier.issn1471-2407
dc.identifier.urihttps://hdl.handle.net/10037/10387
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.journalBMC Cancer
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800en_US
dc.titlePre-diagnostic body mass index and weight change in relation to colorectal cancer survival among incident cases from a population-based cohort studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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