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dc.contributor.authorTiwari, Sweta
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorJacobsen, Bjarne K.
dc.contributor.authorHopstock, Laila Arnesdatter
dc.contributor.authorNyrnes, Audhild
dc.contributor.authorNjølstad, Inger
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorSchirmer, Henrik
dc.date.accessioned2017-03-09T11:16:41Z
dc.date.available2017-03-09T11:16:41Z
dc.date.issued2016-09-01
dc.description.abstractObjective:<br> CHA2DS2-VASc score, left atrial (LA) size and atrial fibrillation (AF) have individually been associated with stroke risk. Our aim was to investigate the predictive ability of combinations of these factors for the odds of incident stroke in a population-based cohort study.<br> Methods:<br> We followed 2844 participants from the Tromsø Study from 1994 to 2012. Information on LA size and CHA2DS2-VASc score (age, sex, congestive heart failure, hypertension, vascular disease, stroke and diabetes) were obtained at baseline. AF status was recorded from medical records. The outcome measure was all strokes. The association between covariates and stroke was investigated by means of multivariate logistic regression analysis.<br> Results:<br> A total of 325 participants (45% women, mean age at baseline 59.3 years) had a stroke. Incidence rates for stroke were 6.4 in women and 8.4 in men per 1000 person-years. Participants with CHA2DS2-VASc ≥1 and LA size <2.8 had ∼4 times (95% CI 2.6 to 5.3) increased odds of stroke, whereas participants with CHA2DS2-VASc ≥1 and LA size ≥2.8 had ∼9 times (95% CI 5.3 to 16.4) increased odds of stroke, compared with participants with CHA2DS2-VASc score 0, irrespective of AF status. Adjustment for significant covariates had minimal impact on the OR estimates.<br> Conclusions:<br> Combining CHA2DS2-VASc score ≥1 and enlarged LA size identified participants with high odds of stroke regardless of AF status.en_US
dc.descriptionSource: <a href=http://dx.doi.org/10.1136/openhrt-2016-000439>doi: 10.1136/openhrt-2016-000439</a>en_US
dc.identifier.citationTiwari S, Løchen M-L, Jacobsen BK, et al. CHA2DS2-VASc score, left atrial size and atrial fibrillation as stroke risk factors in the Tromsø Study. Open Heart 2016;3:e000439. doi:10.1136/openhrt-2016- 000439 ▸en_US
dc.identifier.cristinIDFRIDAID 1380068
dc.identifier.doi10.1136/openhrt-2016-000439
dc.identifier.issn2053-3624
dc.identifier.urihttps://hdl.handle.net/10037/10505
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.journalOpen heart
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.titleCHA2DS2-VASc score, left atrial size and atrial fibrillation as stroke risk factors in the Tromsø Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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