dc.contributor.author | Rushfeldt, Christian | |
dc.contributor.author | Agledahl, Uwe | |
dc.contributor.author | Sveinbjørnsson, Baldur | |
dc.contributor.author | Søreide, Kjetil | |
dc.contributor.author | Wilsgaard, Tom | |
dc.date.accessioned | 2017-03-10T10:32:03Z | |
dc.date.available | 2017-03-10T10:32:03Z | |
dc.date.issued | 2016-11 | |
dc.description.abstract | Background
Perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with risk of anastomotic leak (AL). However, concomitant use of other drugs could infer a bias in risk assessment. Thus, we aimed to interrogate the risk of AL associated with NSAIDs and steroids used perioperatively.
Methods
This study includes a consecutive series of patients having surgery involving an intestinal anastomosis from Jan 2007 to Dec 2009. Data records included demographic, perioperative, and surgical characteristics; AL rates; and use of NSAIDs and steroids. Risk of leak were estimated using unadjusted and multivariable (propensity score)-adjusted logistic regression models and reported as odds ratios (ORs).
Results
A total of 376 patients underwent 428 operations of which 67 (15.7 %) had AL. With no medication receivers as reference, the OR for leak when adjusted for age, sex, and propensity score was 1.07 (p = 0.92) for ketorolac, 1.63 (p = 0.31) for diclofenac and 0.41 (p = 0.19) for dexamethasone. Risk was increased for malignancy (OR 1.88, p = 0.023), use of a vasopressor (OR 2.52, p = 0.007), blood transfusions (OR 1.93, p = 0.026), and regular use of steroids (OR 7.57, p = 0.009).
Conclusions
Other factors than perioperative drugs are crucial for risk of AL. Perioperative dexamethasone was associated with a nonsignificant reduced risk of AL. | en_US |
dc.description | Published version. Source at <a href=http://doi.org/10.1007/s00268-016-3620-0>http://doi.org/10.1007/s00268-016-3620-0</a>.
License <a href=https://creativecommons.org/licenses/by/4.0/>CC BY 4.0</a | en_US |
dc.identifier.citation | Rushfeldt C, Agledahl U, Sveinbjørnsson B, Søreide K, Wilsgaard T. Effect of Perioperative Dexamethasone and Different NSAIDs on Anastomotic Leak Risk: A Propensity Score Analysis. World Journal of Surgery. 2016;40(11):2782-2789 | en_US |
dc.identifier.cristinID | FRIDAID 1402060 | |
dc.identifier.doi | 10.1007/s00268-016-3620-0 | |
dc.identifier.issn | 0364-2313 | |
dc.identifier.issn | 1432-2323 | |
dc.identifier.uri | https://hdl.handle.net/10037/10542 | |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.relation.journal | World Journal of Surgery | |
dc.rights.accessRights | openAccess | en_US |
dc.subject | VDP::Medical disciplines: 700::Clinical medical disciplines: 750::General surgery: 780 | en_US |
dc.title | Effect of Perioperative Dexamethasone and Different NSAIDs on Anastomotic Leak Risk: A Propensity Score Analysis | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |