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dc.contributor.authorRushfeldt, Christian
dc.contributor.authorAgledahl, Uwe
dc.contributor.authorSveinbjørnsson, Baldur
dc.contributor.authorSøreide, Kjetil
dc.contributor.authorWilsgaard, Tom
dc.date.accessioned2017-03-10T10:32:03Z
dc.date.available2017-03-10T10:32:03Z
dc.date.issued2016-11
dc.description.abstractBackground Perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with risk of anastomotic leak (AL). However, concomitant use of other drugs could infer a bias in risk assessment. Thus, we aimed to interrogate the risk of AL associated with NSAIDs and steroids used perioperatively. Methods This study includes a consecutive series of patients having surgery involving an intestinal anastomosis from Jan 2007 to Dec 2009. Data records included demographic, perioperative, and surgical characteristics; AL rates; and use of NSAIDs and steroids. Risk of leak were estimated using unadjusted and multivariable (propensity score)-adjusted logistic regression models and reported as odds ratios (ORs). Results A total of 376 patients underwent 428 operations of which 67 (15.7 %) had AL. With no medication receivers as reference, the OR for leak when adjusted for age, sex, and propensity score was 1.07 (p = 0.92) for ketorolac, 1.63 (p = 0.31) for diclofenac and 0.41 (p = 0.19) for dexamethasone. Risk was increased for malignancy (OR 1.88, p = 0.023), use of a vasopressor (OR 2.52, p = 0.007), blood transfusions (OR 1.93, p = 0.026), and regular use of steroids (OR 7.57, p = 0.009). Conclusions Other factors than perioperative drugs are crucial for risk of AL. Perioperative dexamethasone was associated with a nonsignificant reduced risk of AL.en_US
dc.descriptionPublished version. Source at <a href=http://doi.org/10.1007/s00268-016-3620-0>http://doi.org/10.1007/s00268-016-3620-0</a>. License <a href=https://creativecommons.org/licenses/by/4.0/>CC BY 4.0</aen_US
dc.identifier.citationRushfeldt C, Agledahl U, Sveinbjørnsson B, Søreide K, Wilsgaard T. Effect of Perioperative Dexamethasone and Different NSAIDs on Anastomotic Leak Risk: A Propensity Score Analysis. World Journal of Surgery. 2016;40(11):2782-2789en_US
dc.identifier.cristinIDFRIDAID 1402060
dc.identifier.doi10.1007/s00268-016-3620-0
dc.identifier.issn0364-2313
dc.identifier.issn1432-2323
dc.identifier.urihttps://hdl.handle.net/10037/10542
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalWorld Journal of Surgery
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::General surgery: 780en_US
dc.titleEffect of Perioperative Dexamethasone and Different NSAIDs on Anastomotic Leak Risk: A Propensity Score Analysisen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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