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dc.contributor.authorLu, Yunxia
dc.contributor.authorCross, Amanda J
dc.contributor.authorMurphy, Neil
dc.contributor.authorFreisling, Heinz
dc.contributor.authorTravis, Ruth C
dc.contributor.authorFerrari, Pietro
dc.contributor.authorKatzke, Verena A
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorOlsson, Åsa
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorRenström, Frida
dc.contributor.authorPanico, Salvatore
dc.contributor.authorPala, Valeria
dc.contributor.authorPalli, Domenico
dc.contributor.authorTumino, Rosario
dc.contributor.authorPeeters, Petra H
dc.contributor.authorSiersema, Peter D
dc.contributor.authorBueno-De-Mesquita, HB
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKlinaki, Eleni
dc.contributor.authorTsironis, Christos
dc.contributor.authorAgudo, Antonio
dc.contributor.authorNavarro, Camen
dc.contributor.authorSanchez, Maria-Jose
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorFagherazzi, Guy
dc.contributor.authorRacine, Antoine
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorGunter, Marc J
dc.contributor.authorRiboli, Eilo
dc.date.accessioned2017-03-10T14:08:43Z
dc.date.available2017-03-10T14:08:43Z
dc.date.issued2016-06-13
dc.description.abstractBackground: The etiology of small intestinal cancer (SIC) is largely unknown, and there are very few epidemiological studies published to date. No studies have investigated abdominal adiposity in relation to SIC. <p>Methods: We investigated overall obesity and abdominal adiposity in relation to SIC in the European Prospective Investigation into Cancer and Nutrition (EPIC), a large prospective cohort of approximately half a million men and women from ten European countries. Overall obesity and abdominal obesity were assessed by body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR). Multivariate Cox proportional hazards regression modeling was performed to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs). Stratified analyses were conducted by sex, BMI, and smoking status. <p>Results: During an average of 13.9 years of follow-up, 131 incident cases of SIC (including 41 adenocarcinomas, 44 malignant carcinoid tumors, 15 sarcomas and 10 lymphomas, and 21 unknown histology) were identified. WC was positively associated with SIC in a crude model that also included BMI (HR per 5-cm increase = 1.20, 95 % CI 1.04, 1.39), but this association attenuated in the multivariable model (HR 1.18, 95 % CI 0.98, 1.42). However, the association between WC and SIC was strengthened when the analysis was restricted to adenocarcinoma of the small intestine (multivariable HR adjusted for BMI = 1.56, 95 % CI 1.11, 2.17). There were no other significant associations. <p>Conclusion: WC, rather than BMI, may be positively associated with adenocarcinomas but not carcinoid tumors of the small intestine. <p>Impact: Abdominal obesity is a potential risk factor for adenocarcinoma in the small intestine.en_US
dc.descriptionPublished version. Source at <a href=http://dx.doi.org/10.1007/s10552-016-0772-z> http://dx.doi.org/10.1007/s10552-016-0772-z </a>en_US
dc.identifier.citationLu, Y. et.al.: Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort. Cancer Causes and Control. 2016;27:919-927en_US
dc.identifier.cristinIDFRIDAID 1369608
dc.identifier.doi10.1007/s10552-016-0772-z
dc.identifier.issn0957-5243
dc.identifier.issn1573-7225
dc.identifier.urihttps://hdl.handle.net/10037/10548
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalCancer Causes and Control
dc.rights.accessRightsopenAccessen_US
dc.subjectAbdominal obesityen_US
dc.subjectObesityen_US
dc.subjectCanceren_US
dc.subjectSmall intestineen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750en_US
dc.titleComparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohorten_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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