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dc.contributor.authorTichelaar, Ynse Ieuwe Gerardus Vladimir
dc.contributor.authorBrodin, Ellen Elisabeth
dc.contributor.authorVik, Anders
dc.contributor.authorIsaksen, Trond
dc.contributor.authorSkjeldestad, Finn Egil
dc.contributor.authorKumar, Satish
dc.contributor.authorTrasti, Nora
dc.contributor.authorSingh, Kulbir
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2017-03-10T14:38:26Z
dc.date.available2017-03-10T14:38:26Z
dc.date.issued2016
dc.description.abstractBackground: Recent studies have suggested that catheterdirected thrombolysis (CDT) reduces development of postthrombotic syndrome (PTS). Ultrasound-assisted CDT (USCDT) might enhance the efficiency of thrombolysis. We aimed to compare USCDT with CDT on efficacy, safety, development of PTS, and quality of life after longterm follow-up. <p>Methods: We describe a retrospective case series of 94 consecutive patients admitted with iliofemoral or more proximal deep vein thrombosis (DVT) to the University Hospital from 2002 to 2011, treated either with CDT or USCDT. Scheduled follow-up visits took place between April 2013 and January 2014. Venography measured the degree of residual luminal obstruction of the affected veins. Each patient completed the Short Form 36-item health survey assessment and the Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms questionnaires. PTS was assessed using the Villalta scale. <p>Results: Risk factors of DVT were equally distributed between groups. In the USCDT group, we observed a significant decline in the duration of thrombolytic treatment (\48 h: 27 vs. 10 %), shortened hospital stay (median 6.0 days (IQR 5.0–9.0) vs. 8.0 (IQR 5.8–12.0)), and less implantation of (intravenous) stents (30 vs. 55 %). There was no difference in patency (76 vs. 79 % fully patent), prevalence of PTS (52 vs. 55 %), or quality of life between groups after long-term follow-up (median 65 months, range: 15–141). <p>Conclusions: In this observational study, USCDT was associated with shortened treatment duration, shorter hospital stay, and less intravenous stenting, compared to CDT alone without affecting the long-term prevalence of PTS or quality of life.en_US
dc.descriptionPublished version. Source at <a href=http://dx.doi.org/10.1007/s00270-016-1367-5> http://dx.doi.org/10.1007/s00270-016-1367-5 </a>en_US
dc.identifier.citationTichelaar YIGV. et.al.: A retrospective comparison of ultrasound-assisted catheter-directed thrombolysis and catheter-directed thrombolysis alone for treatment of proximal deep vein thrombosis. Cardiovascular and Interventional Radiology. 2016;39(8):1115-1121en_US
dc.identifier.cristinIDFRIDAID 1370880
dc.identifier.doi10.1007/s00270-016-1367-5
dc.identifier.issn0174-1551
dc.identifier.issn1432-086X
dc.identifier.urihttps://hdl.handle.net/10037/10550
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalCardiovascular and Interventional Radiology
dc.rights.accessRightsopenAccessen_US
dc.subjectCatheteren_US
dc.subjectThrombolysisen_US
dc.subjectUltrasounden_US
dc.subjectVenous thrombosisen_US
dc.subjectQuality of lifeen_US
dc.subjectPost-thrombotic syndromeen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750en_US
dc.titleA retrospective comparison of ultrasound-assisted catheter-directed thrombolysis and catheter-directed thrombolysis alone for treatment of proximal deep vein thrombosisen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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