Magnetic resonance volumetry: prediction of subjective memory complaints and mild cognitive impairment, and associations with genetic and cardiovascular risk factors
ForfatterRogne, Sigbjørn Olav; Vangberg, Torgil Riise; Eldevik, Odd Petter; Wikran, Gry Charlotte; Mathiesen, Ellisiv B.; Schirmer, Henrik
Methods: 198 stroke-free subjects comprised the control (n =58), the SMC (n = 25) and the MCI (n = 115) groups. Analysis of covariance and receiver operating characteristic curve was used to see if MR volumetry distinguished subjects with SMC and MCI from controls.
Results: Subjects with SMC and MCI had significantly larger lateral ventricles and smaller hippocampal volumes than controls. The area under the curve in subjects with SMC and MCI compared to that of controls was less than 0.68 for all volumes of intracranial structures. There was an interaction between sex and probable parental LOAD for hippocampal volume, with a significant association between probable parental LOAD and hippocampal volume in women.
Conclusions: Fully automated MR volumetry can distinguish subjects with SMC and MCI from controls in a general population, but insufficiently to assume a clear clinical role. Research on sporadic LOAD might benefit from a sex-specific search for genetic risk factors.