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Serine-aspartate-repeat protein D Increases Staphylococcus aureus Virulence and Survival in Blood

Permanent link
https://hdl.handle.net/10037/10604
DOI
https://doi.org/10.1128/IAI.00559-16
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Date
2016-10-17
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Askarian, Fatemeh; Uchiyama, Satoshi; Valderrama, J. Andrés; Ajayi, Clement; Sollid, Johanna U. E.; Van Sorge, Nina M.; Nizet, Victor; van strijp, Jos A. G.; Johannessen, Mona
Abstract
Staphylococcus aureus expresses a panel of cell wall-anchored adhesins, including proteins belonging to the microbial surface components recognizing adhesive matrix molecule (MSCRAMM) family, exemplified by the serine-aspartate repeat protein D (SdrD), which serve key roles in colonization and infection. Deletion of sdrD from S. aureus subsp. aureus strain NCTC8325-4 attenuated bacterial survival in human whole blood ex vivo, which was associated with increased killing by human neutrophils. Remarkably, SdrD was able to inhibit innate immune-mediated bacterial killing independently of other S. aureus proteins, since addition of recombinant SdrD protein and heterologous expression of SdrD in Lactococcus lactis promoted bacterial survival in human blood. SdrD contributes to bacterial virulence in vivo, since fewer S. aureus subsp. aureus NCTC8325-4 ΔsdrD bacteria than bacteria of the parent strain were recovered from blood and several organs using a murine intravenous infection model. Collectively, our findings reveal a new property of SdrD as an important key contributor to S. aureus survival and the ability to escape the innate immune system in blood.
Description
Source: http://dx.doi.org/10.1128/IAI.00559-16
Is part of
Ajayi, C. (2018). Determinants of Staphylococcus aureus Colonization and Infection. “Exploring the Role of Cell Wall Anchored Proteins in Adhesion and Immune Evasion”. Doctoral thesis. http://hdl.handle.net/10037/14070
Publisher
American Society for Microbiology
Citation
Askarian, F., Uchlyama, S., Valderrama, J.A., Ajayi, C., Sollid, J.U.E., van Sorge, N.M. ... Johannessen, M. (2016). Serine-Aspartate Repeat Protein D Increases Staphylococcus aureus Virulence and Survival in Blood. Infection and Immunity, 85(1), e00559-16. https://doi.org/10.1128/IAI.00559-16.
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