ub.xmlui.mirage2.page-structure.muninLogoub.xmlui.mirage2.page-structure.openResearchArchiveLogo
    • EnglishEnglish
    • norsknorsk
  • Velg spraakEnglish 
    • EnglishEnglish
    • norsknorsk
  • Administration/UB
View Item 
  •   Home
  • Det helsevitenskapelige fakultet
  • Institutt for klinisk medisin
  • Artikler, rapporter og annet (klinisk medisin)
  • View Item
  •   Home
  • Det helsevitenskapelige fakultet
  • Institutt for klinisk medisin
  • Artikler, rapporter og annet (klinisk medisin)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Development of a feasible and responsive ultrasound inflammation score for rheumatoid arthritis through a data-driven approach

Permanent link
https://hdl.handle.net/10037/10795
DOI
https://doi.org/10.1136/rmdopen-2016-000325
Thumbnail
View/Open
article.pdf (839.7Kb)
(PDF)
Date
2016-12-16
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Aga, Anna-Birgitte; Hammer, Hilde Berner; Olsen, Inge Christoffer; Uhlig, Till; Kvien, Tore Kristian; Heijde, Desirée van der; Fremstad, Hallvard; Madland, Tor Magne; Lexberg, Åse; Haukeland, Hilde; Rødevand, Erik; Høili, Christian; Stray, Hilde; Noraas, Anne Lindtner; Hansen, Inger Johanne Widding; Bakland, Gunnstein; Lillegraven, Siri; Lie, Elisabeth; Haavardsholm, Espen A.
Abstract
Objective: To develop and validate a responsive and feasible ultrasound inflammation score for rheumatoid arthritis (RA). Methods: We used data from cohorts of early RA (development) and established RA starting/switching biologic therapy (validation). 4 tendons and 36 joints were examined by a grey scale (GSUS) and power Doppler semiquantitative ultrasound (PDUS) scoring system (full score). Ultrasound score components were selected based on factor analyses of 3-month change in the development cohort. Responsiveness was assessed by standardised response means (SRMs). We assessed the proportion of information retained from the full score by linear regression. Results: 118 patients with early and 212 patients with established RA were included. The final ultrasound score included 8 joints (metacarpophalangeal 1–2–3, proximal interphalangeal 2–3, radiocarpal, metatarsophalangeal 2–3) and 1 tendon (extensor carpi ulnaris) examined bilaterally. The 6-month SRMs for the final score were −1.24 (95% CI −1.47 to −1.02) for GSUS, and −1.09 (−1.25 to −0.92) for PDUS in early RA, with 87% of total information retained for GSUS and 90% for PDUS. The new score performed somewhat better than formerly proposed scores in the validation cohort. Conclusions: The Ultrasound in Rheumatoid Arthritis 9 joint/tendon score (USRA9) inflammation score showed good responsiveness, retained most of the information from the original full score and overall performed better than previous scores in a validation cohort.
Description
Published version. Source at http://doi.org/10.1136/rmdopen-2016-000325. License CC BY 4.0.
Publisher
BMJ Publishing Group
Citation
Aga A, Hammer Hb, Olsen IC, Uhlig T, Kvien TK, Heijde Dvd, Fremstad H, Madland TM, Lexberg Å, Haukeland H, Rødevand E, Høili C, Stray H, Noraas, Hansen IJW, Bakland G, Lillegraven S, Lie E, Haavardsholm EA. Development of a feasible and responsive ultrasound inflammation score for rheumatoid arthritis through a data-driven approach. RMD Open. 2016;2(2)
Metadata
Show full item record
Collections
  • Artikler, rapporter og annet (klinisk medisin) [1974]

Browse

Browse all of MuninCommunities & CollectionsAuthor listTitlesBy Issue DateBrowse this CollectionAuthor listTitlesBy Issue Date
Login

Statistics

View Usage Statistics
UiT

Munin is powered by DSpace

UiT The Arctic University of Norway
The University Library
uit.no/ub - munin@ub.uit.no

Accessibility statement (Norwegian only)