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The presence of intraepithelial CD45RO+ cells in resected lymph nodes with metastases from NSCLC patients is an independent predictor of disease-specific survival

Permanent lenke
https://hdl.handle.net/10037/10822
DOI
https://doi.org/10.1038/bjc.2016.92
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article.pdf (580.0Kb)
publisher's pdf (PDF)
Dato
2016-04-07
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Kilvær, Thomas Karsten; Paulsen, Erna-Elise; Rakaee, Mehrdad; Al-Saad, Samer; Johansen Maurseth, Ramona; Al-Shibli, Khalid; Bremnes, Roy M.; Busund, Lill-Tove; Dønnem, Tom
Sammendrag
background: Operable non-small cell lung cancer (NSCLC) patients whose tumours have spread to regional or central lymph nodes at the time of diagnosis have dismal prognoses compared with those who have limited disease. The current TNM staging system for NSCLC poorly distinguishes patients with lymph-node metastases who will succumb to, and those who will eventually be cured from, their disease. This novel study: (1) evaluates the presence of different subsets of intraepithelial tumour-infiltrating lymphocytes (TILs) in lymph nodes with metastases from NSCLC patients; (2) explores the impact of intraepithelial TILs in lymph nodes on survival; (3) correlates their presence with both intraepithelial and stromal TILs in their corresponding primary tumours. methods: Metastatic lymph-node tissue from 143N+ NSCLC patients was collected and tissue microarrays were constructed. Immunohistochemistry was used to evaluate the presence of intraepithelial CD3+, CD4+, CD8+, CD20+ and CD45RO+ TILs and their impact on survival. results: A high level of intraepithelial CD45RO+ TILs in lymph-node metastases from N+ NSCLC patients was an independent positive prognostic factor for disease-specific survival in all patients (HR=0.58, P=0.029) and in squamous cell carcinoma (HR=0.31, P=0.006), but not in adenocarcinoma patients. conclusions: The presence of intraepithelial CD45RO+ cells in lymph-node metastases from N+ NSCLC patients predicts favourable disease-specific survival and outperforms the established TNM staging system in the SCC subgroup.
Beskrivelse
Published version. Source at http://doi.org/10.1038/bjc.2016.92. License CC BY-NC-SA 4.0.
Forlag
Cancer Research UK
Sitering
Kilvær et al. The presence of intraepithelial CD45RO+ cells in resected lymph nodes with metastases from NSCLC patients is an independent predictor of disease-specific survival. British Journal of Cancer. 2016;114(10):1145-1151
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  • Artikler, rapporter og annet (klinisk medisin) [1974]

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