Show simple item record

dc.contributor.authorLauritzen, Hilde Brun
dc.contributor.authorLarose, Tricia L
dc.contributor.authorØien, Torbjørn
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorOdland, Jon Øyvind
dc.contributor.authorvan de Bor, Margot
dc.contributor.authorJacobsen, Geir Wenberg
dc.date.accessioned2017-03-29T14:57:24Z
dc.date.available2017-03-29T14:57:24Z
dc.date.issued2016-10-26
dc.description.abstract<b>Background:</b> The associations between prenatal exposure to endocrine disruptive chemicals (EDCs) and fetal growth are inconsistent, and few studies have considered small-for-gestational-age (SGA) birth as an outcome. Our current study of Scandinavian parous women aimed to address these inconsistencies and gaps in the literature.<br> <b>Methods:</b> This case–cohort study included 424 mother– child pairs who participated in a prospective, multi-center study of parous women in Norway (Trondheim and Bergen) and Sweden (Uppsala). We used linear and logistic regression with 95% confidence intervals (CIs) to analyze the associations between two perfluoroalkyl substances (PFASs) and five organochlorines (OCs) from early second trimester and indices of fetal growth.<br> <b>Results:</b> Among Swedish women, prenatal exposure to perfluorooctanoate (PFOA), polychlorinated biphenyl (PCB) 153 and hexachlorobenzene (HCB) were associated with higher odds for SGA birth. We found stronger associations among Swedish male offspring. In the Norwegian cohort, we found no significant associations between EDC exposure and indices of fetal growth.<br> <b>Conclusions:</b> Some populations may be more vulnerable to EDCs, possibly due to differences in exposure levels, exposure sources and/or modifiable lifestyle factors. Male offspring may be more vulnerable to endocrine disruption.en_US
dc.description© The Author(s) (2016). This work is licensed under a <a href="http://creativecommons.org/licenses/by-nc-nd/4.0/">Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License.</a> The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. <a href="http://dx.doi.org/10.1038/pr.2016.187">DOI: 10.1038/pr.2016.187</a>en_US
dc.identifier.citationLauritzen HB, Larose TL, Øien TØ, Sandanger TM, Odland j, van de Bor, Jacobsen GWJ. Maternal serum levels of perfluoroalkyl substances and organochlorines and indices of fetal growth: a Scandinavian case-cohort study. Pediatric Research. 2016;81(1)en_US
dc.identifier.cristinIDFRIDAID 1374042
dc.identifier.doidoi:10.1038/pr.2016.187
dc.identifier.issn0031-3998
dc.identifier.issn1530-0447
dc.identifier.urihttps://hdl.handle.net/10037/10897
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.relation.journalPediatric Research
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.titleMaternal serum levels of perfluoroalkyl substances and organochlorines and indices of fetal growth: a Scandinavian case-cohort studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record