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dc.contributor.authorChi, Heng
dc.contributor.authorBøgwald, Jarl
dc.contributor.authorDalmo, Roy Ambli
dc.contributor.authorZhang, Wenjie
dc.contributor.authorHu, Yong-hua
dc.date.accessioned2017-03-31T10:10:19Z
dc.date.available2017-03-31T10:10:19Z
dc.date.issued2015-11-10
dc.description.abstractThe RAR-related orphan receptors (RORs) are members of the nuclear receptor family of intracellular transcription factors. In this study, we examined the regulatory properties of RORα (CsRORα) and RORγ (CsRORγ) in tongue sole (Cynoglossus semilaevis). CsRORα and CsRORγ expression was detected in major lymphoid organs and altered to significant extents after bacterial and viral infection. CsRORα enhanced the activities of CsIL-17C, CsIL-17D, and CsIL-17F promoters, which contain CsRORα and CsRORγ binding sites. CsRORγ also upregulated the promoter activities of CsIL-17D and CsIL-17F but not CsIL-17C. CsRORα and CsRORγ proteins were detected in the nucleus, and overexpression of CsRORα in tongue sole significantly increased the expression of CsIL-17C, CsIL-17D, and CsIL-17F, whereas overexpression of CsRORγ significantly increased the expression of CsIL-17C and CsIL-17F but no CsIL-17D. These results indicate that RORα and RORγ in teleost regulate the expression of IL-17 members in different manners.en_US
dc.descriptionManuscript. Source at <a href=http://dx.doi.org/10.1016/j.dci.2015.11.001> http://dx.doi.org/10.1016/j.dci.2015.11.001 </a>en_US
dc.identifier.citationChi H, Bøgwald J, Dalmo RA, Zhang, Hu. Th17 master transcription factors RORα and RORγ regulate the expression of IL-17C, IL-17D and IL-17F in Cynoglossus semilaevis. Developmental and Comparative Immunology. 2016;55:169-178en_US
dc.identifier.cristinIDFRIDAID 1360664
dc.identifier.doi10.1016/j.dci.2015.11.001
dc.identifier.issn0145-305X
dc.identifier.issn1879-0089
dc.identifier.urihttps://hdl.handle.net/10037/10916
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalDevelopmental and Comparative Immunology
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480::Marine biology: 497en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Marinbiologi: 497en_US
dc.subjectRORαen_US
dc.subjectRORγen_US
dc.subjectIL-17en_US
dc.subjectPromoter activityen_US
dc.subjectCynoglossus semilaevisen_US
dc.titleTh17 master transcription factors RORα and RORγ regulate the expression of IL-17C, IL-17D and IL-17F in Cynoglossus semilaevisen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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