Background: Ovarian carcinomas from 30 BRCA1 germ-line carriers of two distinct high penetrant founder mutations, 20 carrying the 1675delA and 10 the 1135insA, and 100 sporadic cases were characterized for somatic mutations in the TP53 gene. We analyzed differences in relation to BRCA1 germline status, TP53 status, survival and age at diagnosis, as previous studies have not been conclusive. Methods: ...

Objectives. To examine the relationship between ‘‘traditional Sami’’ dietary pattern and mortality in a general northern Swedish population. Study design. Population-based cohort study.<p> <p>Methods. We examined 77,319 subjects from the Va¨sterbotten Intervention Program (VIP) cohort. A traditional Sami diet score was constructed by adding 1 point for intake above the median level of red meat, ...

Background - Body fatness is a dynamic exposure throughout life. To provide more insight into the association between body mass index (BMI) and postmenopausal breast cancer, we aimed to examine the age at onset, duration, intensity, and trajectories of body fatness in adulthood in relation to risk of breast cancer subtypes.<p> <p>Methods - Based on self-reported anthropometry in the prospective ...

Introduction - The purpose of this study is to explore treatment preferences and identify patient characteristics in young bio-naive adults with moderate to severe psoriasis in the Nordic countries (Norway, Finland, Sweden, and Denmark).<p> <p>Methods - Patients were 18–45 years old and bio-naive but referred for biologic treatment of moderate to severe psoriasis. Patients were included at eight ...

Objective: Pattern analysis has emerged as a tool to depict the role of multiple nutrients/foods in relation to health outcomes. The present study aimed at extracting nutrient patterns with respect to breast cancer (BC) aetiology.<br> Design: Nutrient patterns were derived with treelet transform (TT) and related to BC risk. TT was applied to twenty-three log-transformed nutrient densities ...

Objective - To assess initiation of hormonal contraception among women aged 15-19 in the US and Norway by birth cohort.<p> <p>Study design - We used population-based survey (US) and administrative (Norway) data to estimate the cumulative probability of age at first use of hormonal contraception for female residents born between 1989 and 1997 in 3-year birth cohorts. Differences between countries ...

BAKGRUNN - Sogn og Fjordane fylke har i landsmålestokk, og serleg i høve til dei andre fylka i Helse Vest, hatt eit høgt forbruk av spesialisthelsetenester. Utover det at fylket har to små lokalsjukehus, har lite vore kjent som kunne forklare det høge forbruket, og serskilt ikkje om det eksisterer kontrastar i forbruk mellom kommunane i fylket.<p> <p>MATERIALE OG METODE - Med utgangspunkt i ...

<p><i>Background</i>: The prison situations are notorious for causing interruptions of tuberculosis (TB) treatment and occurrence of unfavorable outcomes. In Ethiopian prisons, though TB treatment programs exist, treatment outcome results and factors contributing to unsuccessful outcome are not well documented. In this study, we assessed the treatment outcome of TB cases and identified risk factors ...

Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated cases and 4362 controls of European ancestry and identify two high-risk loci associated with WM/LPL at 6p25.3 (rs116446171, near EXOC2 and IRF4; OR = 21.14, 95% CI: 14.40–31.03, P = 1.36 × 10<s ...