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dc.contributor.authorHinks, A
dc.contributor.authorBowes, J
dc.contributor.authorCobb, J
dc.contributor.authorAinsworth, HC
dc.contributor.authorMarion, MC
dc.contributor.authorComeau, ME
dc.contributor.authorSudman, M
dc.contributor.authorHan, B
dc.contributor.authorBecker, ML
dc.contributor.authorBohnsack, JF
dc.contributor.authorde Bakker, PIW
dc.contributor.authorHaas, JP
dc.contributor.authorHazen, M
dc.contributor.authorLovell, DJ
dc.contributor.authorNigrovic, PA
dc.contributor.authorNordal, Ellen Berit
dc.contributor.authorPunnaro, M
dc.contributor.authorRosenberg, AM
dc.contributor.authorRygg, Marite
dc.contributor.authorSmith, S.L.
dc.contributor.authorWise, CA
dc.contributor.authorVidem, Vibeke
dc.contributor.authorWedderburn, LR
dc.contributor.authorYarwood, A
dc.contributor.authorYeung, RSM
dc.contributor.authorPrahalad, S
dc.contributor.authorLangefeld, CD
dc.contributor.authorRaychaudhuri, S
dc.contributor.authorThompson, SD
dc.contributor.authorThomson, W
dc.date.accessioned2017-09-13T11:11:25Z
dc.date.available2017-09-13T11:11:25Z
dc.date.issued2016-12-20
dc.description.abstractObjectives: Juvenile idiopathic arthritis ( JIA) is a heterogeneous group of diseases, comprising seven categories. Genetic data could potentially be used to help redefine JIA categories and improve the current classification system. The human leucocyte antigen (HLA) region is strongly associated with JIA. Fine-mapping of the region was performed to look for similarities and differences in HLA associations between the JIA categories and define correspondences with adult inflammatory arthritides. <br>Methods: Dense genotype data from the HLA region, from the Immunochip array for 5043 JIA cases and 14 390 controls, were used to impute single-nucleotide polymorphisms, HLA classical alleles and amino acids. Bivariate analysis was performed to investigate genetic correlation between the JIA categories. Conditional analysis was used to identify additional effects within the region. Comparison of the findings with those in adult inflammatory arthritic diseases was performed. <br>Results: We identified category-specific associations and have demonstrated for the first time that rheumatoid factor (RF)-negative polyarticular JIA and oligoarticular JIA are genetically similar in their HLA associations. We also observe that each JIA category potentially has an adult counterpart. The RF-positive polyarthritis association at HLA-DRB1 amino acid at position 13 mirrors the association in adult seropositive rheumatoid arthritis (RA). Interestingly, the combined oligoarthritis and RF-negative polyarthritis dataset shares the same association with adult seronegative RA. <br>Conclusions: The findings suggest the value of using genetic data in helping to classify the categories of this heterogeneous disease. Mapping JIA categories to adult counterparts could enable shared knowledge of disease pathogenesis and aetiology and facilitate transition from paediatric to adult services.en_US
dc.descriptionSource at <a href=http://dx.doi.org/10.1136/annrheumdis-2016-210025> http://dx.doi.org/10.1136/annrheumdis-2016-210025 </a>en_US
dc.identifier.citationHinks A, Bowes J, Cobb J, et al. Ann Rheum Dis 2016. doi:10.1136/ annrheumdis-2016-210025en_US
dc.identifier.cristinIDFRIDAID 1484455
dc.identifier.doi10.1136/annrheumdis-2016-210025
dc.identifier.issn0003-4967
dc.identifier.issn1468-2060
dc.identifier.urihttps://hdl.handle.net/10037/11442
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.journalAnnals of the Rheumatic Diseases
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Rheumatology: 759en_US
dc.titleFine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseasesen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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