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dc.contributor.authorSawada, Norie
dc.contributor.authorWark, Petra A.
dc.contributor.authorMerritt, Melissa A.
dc.contributor.authorTsugane, Shoichiro
dc.contributor.authorWard, Heather A.
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorDartois, Laureen
dc.contributor.authorHis, Mathilde
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorTurzanski-Fortner, Renée
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorOvervad, Kim
dc.contributor.authorRedondo, María-Luisa
dc.contributor.authorTravier, Noemie
dc.contributor.authorMolina-Portillo, Elena
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorCirera, Lluis
dc.contributor.authorArdanaz, Eva
dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLagiou, Pagona
dc.contributor.authorValanou, Elissavet
dc.contributor.authorMasala, Giovanna
dc.contributor.authorPala, Valeria
dc.contributor.authorPeeters, Petra H.M.
dc.contributor.authorvan der Schouw, Yvonne T.
dc.contributor.authorMelander, Olle
dc.contributor.authorManjer, Jonas
dc.contributor.authorda Silva, Marisa Eleonor
dc.contributor.authorSkeie, Guri
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOlsen, Anja
dc.contributor.authorGunter, Mark J.
dc.contributor.authorRiboli, Elio
dc.contributor.authorCross, Amanda J.
dc.date.accessioned2017-12-09T11:53:54Z
dc.date.available2017-12-09T11:53:54Z
dc.date.issued2017-03-03
dc.description.abstractAdult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in ~253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: HRQ5 vs. Q1 = 1.11, 95%CI = 1.00–1.24; women: HRQ5 vs. Q1 = 1.17, 95%CI = 1.07–1.28). In contrast, height was inversely associated with circulatory disease mortality (men: HRQ5 vs. Q1 = 0.63, 95%CI = 0.56–0.71; women: HRQ5 vs. Q1 = 0.81, 95%CI = 0.70–0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: HRQ5 vs. Q1 = 0.64, 95%CI = 0.55–0.75; women: HRQ5 vs. Q1 = 0.60, 95%CI = 0.49–0.74) and respiratory disease mortality (men: HRQ5 vs. Q1 = 0.45, 95%CI = 0.28–0.71; women: HRQ5 vs. Q1 = 0.60, 95%CI = 0.40–0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.en_US
dc.descriptionSource at <a href=https://doi.org/10.1371/journal.pone.0173117> https://doi.org/10.1371/journal.pone.0173117 </a>en_US
dc.identifier.citationSawada N. et al.: The association between adult attained height and sitting height with mortality in the European prospective investigation into cancer and nutrition (EPIC). PLoS ONE. 2017;12:e0173117(3):1-17en_US
dc.identifier.cristinIDFRIDAID 1489906
dc.identifier.doi10.1371/journal.pone.0173117
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/11838
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.journalPLoS ONE
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleThe association between adult attained height and sitting height with mortality in the European prospective investigation into cancer and nutrition (EPIC)en_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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