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dc.contributor.authorNorvik, Jon Viljar
dc.contributor.authorSchirmer, Henrik
dc.contributor.authorYtrehus, Kirsti
dc.contributor.authorJenssen, Trond Geir
dc.contributor.authorZykova, Svetlana
dc.contributor.authorEggen, Anne Elise
dc.contributor.authorEriksen, Bjørn Odvar
dc.contributor.authorSolbu, Marit Dahl
dc.date.accessioned2018-01-08T07:38:15Z
dc.date.available2018-01-08T07:38:15Z
dc.date.issued2017-03-14
dc.description.abstractBackground: Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfunction, and whether the association was sex dependent. <br>Methods: We conducted a cross-sectional study on 1165 women and 896 men without diabetes. We stratified the multivariable adjusted logistic regression analyses and the fractional polynomi al regression analyses according to sex, with echocardiographic markers of diastolic dysfunction as dependent variables, and adiponectin as the independent variable of interest. <br>Results: Decreased adiponectin was associated with higher odds of average tissue Doppler e ’ < 9 in women (odds ratio [OR] 1.17 per 1 μ g/mL adiponectin decrease, 95% confidence interval [CI] 1.04 – 1.30), but not in men (p for interaction with sex 0.04). Women, but not men, had higher odds of E/e ’ ratio ≥ 8 with lower adiponectin (OR 1.12 per 1 μ g/mL adiponectin decrease, 95% CI 1.02 – 1.24, p for interaction with sex 0.04). Adiponectin in the lower sex-specific tertile was associated with increased odds of concentric left ventricular hypertrophy in women (OR 2.44, 95% CI 1.03 – 5.77), but with decreased odds in men (OR 0.32, 95% CI 0.11 – 0.88, p for interaction with sex 0.002), and decreased odds of eccentric hypertrophy in men only (OR 0.53, 95% CI 0.33 – 0.88, p for interaction with sex 0.02). Adiponectin in the lower sex-specific tertile was associated with moderately enlarged left atria in women only (OR 1.43, 95% CI 1.01 – 2.03, p for interaction with sex 0.04). Finally, adiponectin had a non-linear relationship with left ventricular mass in women only, with exponentially increasing left ventricular mass with lower adiponectin levels (p for interaction with sex 0.01). <br>Conclusions: Low adiponectin was associated with higher odds of indices of diastolic dysfunction in women, but lower odds of indices of diastolic dysfunction in men. Lower adiponectin was associated with increased left ventricular mass in women only.en_US
dc.descriptionSource at <a href=https://doi.org/10.1186/s12872-017-0509-2> https://doi.org/10.1186/s12872-017-0509-2 </a>en_US
dc.identifier.citationNorvik JV, Schirmer H, Ytrehus K, Jenssen TG, Zykova S, Eggen AE, Eriksen BO, Solbu MD. Low adiponectin is associated with diastolic dysfunction in women: A cross-sectional study from the Tromsø Study. BMC Cardiovascular Disorders. 2017;17:79:1-10en_US
dc.identifier.issn1471-2261
dc.identifier.otherFRIDAID 1489578
dc.identifier.other10.1186/s12872-017-0509-2
dc.identifier.urihttp://hdl.handle.net/10037/11921
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.journalBMC Cardiovascular Disorders
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774en_US
dc.titleLow adiponectin is associated with diastolic dysfunction in women: A cross-sectional study from the Tromsø Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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