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dc.contributor.authorTalibov, Madar
dc.contributor.authorAuvinen, Anssi
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorHansen, Johnni
dc.contributor.authorMartinsen, Jan Ivar
dc.contributor.authorKjærheim, Kristina
dc.contributor.authorTryggvadóttir, Laufey
dc.contributor.authorPukkala, Eero
dc.date.accessioned2018-02-01T13:37:02Z
dc.date.available2018-02-01T13:37:02Z
dc.date.issued2017-06-15
dc.description.abstractThe aim of this study was to assess the effect of occupational solvent exposure on the risk of adult chronic lymphocytic leukemia (CLL). The current case–control study was nested in the Nordic Occupational Cancer Study (NOCCA) cohort. 20,615 CLL cases diagnosed in 1961–2005 in Finland, Iceland, Norway, and Sweden, and 103,075 population-based controls matched by year of birth, sex, and country were included. Occupational histories for cases and controls were obtained from census records in 1960, 1970, 1980/1981, and 1990. Exposure to selected solvents was estimated by using the NOCCA job-exposure matrix (NOCCA-JEM). Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by using conditional logistic regression models. Overall, nonsignificant CLL risk elevations were observed for methylene chloride, perchloroethylene, and 1,1,1-trichloroethane. Compared to unexposed, significantly increased risks were observed for cumulative perchloroethylene exposure ≤13.3 ppm-years (OR = 1.85, 95% CI 1.16–2.96) and average life-time perchloroethylene exposure ≤2.5 ppm (1.61, 95% CI 1.01–2.56) among women, and cumulative methylene chloride exposure ≤12.5 ppm-years (OR = 1.19, 95% CI 1.01–1.41) and 12.5–74.8 ppm-years (OR = 1.23, 95% CI 1.01–1.51) among men in an analysis with 5 years lag-time, though without dose–response pattern. Decreased CLL risk was observed for aliphatic and alicyclic hydrocarbon solvents and toluene. This study did not support associations for solvent exposure and CLL. Observed weak associations for methylene chloride, perchloroethylene, 1,1,1-trichloroethane exposures, aliphatic and alicyclic hydrocarbons and toluene were not consistent across sexes, and showed no gradient with amount of exposure.en_US
dc.descriptionAccepted manuscript version. Published version available in <a href=http://dx.doi.org/10.1002/ijc.30814>International Journal of Cancer. 2017;141(6):1140-1147</a>en_US
dc.identifier.citationTalibov, M., Auvinen, A., Weiderpass, E., Hansen, J., Martinsen, J.I., Kjærheim, K.J., ... Pukkala, E. (2017). Occupational solvent exposure and adult chronic lymphocytic leukemia: No risk in a population-based case-control study in four Nordic countries. International Journal of Cancer. 2017;141(6):1140-1147en_US
dc.identifier.cristinIDFRIDAID 1514174
dc.identifier.doi10.1002/ijc.30814
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttps://hdl.handle.net/10037/12074
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.titleOccupational solvent exposure and adult chronic lymphocytic leukemia: No risk in a population-based case-control study in four Nordic countriesen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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