Show simple item record

dc.contributor.authorWard, Heather A.
dc.contributor.authorWark, Petra A.
dc.contributor.authorMuller, David C.
dc.contributor.authorSteffen, Annika
dc.contributor.authorJohansson, Mattias
dc.contributor.authorNorat, Teresa
dc.contributor.authorGunter, Marc J.
dc.contributor.authorOvervad, Kim
dc.contributor.authorDahm, Christina C
dc.contributor.authorHalkjær, Jytte
dc.contributor.authorTjønneland, Anne
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorFagherazzi, Guy
dc.contributor.authorMesrine, Sylvie
dc.contributor.authorBrennan, Paul
dc.contributor.authorFreisling, Heinz
dc.contributor.authorLi, Kuanrong
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLagiou, Pagona
dc.contributor.authorPanico, Salavatore
dc.contributor.authorGrioni, Sara
dc.contributor.authorTumino, Rosario
dc.contributor.authorVineis, Paolo
dc.contributor.authorPalli, Domenico
dc.contributor.authorPeeters, Petra H.M.
dc.contributor.authorBueno-De-Mesquita, Hendrik Bastiaan
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorAgudo, Antonio
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorLarrañaga, Nerea
dc.contributor.authorArdanaz, Eva
dc.contributor.authorHuerta, José María
dc.contributor.authorSánchez, María-José
dc.contributor.authorLaurell, Göran
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorWestin, Ulla
dc.contributor.authorWallström, Peter
dc.contributor.authorBradbury, Kathryn E.
dc.contributor.authorWareham, Nicholas J.
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorPearson, Clare
dc.contributor.authorBoeing, Heiner
dc.contributor.authorRiboli, Elio
dc.date.accessioned2018-02-01T14:43:07Z
dc.date.available2018-02-01T14:43:07Z
dc.date.issued2017-06
dc.description.abstract<b>Background</b>: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer. However, most studies have used self-reported anthropometry which is prone to error.<br><b>Methods</b>: Among 363,094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of head and neck cancer. Head and neck cancer risk was examined in relation to body mass index (BMI) [lean: <22.5 kg/m2, normal weight (reference): 22.5–24.9 kg/m2, overweight 25–29.9 kg/m2, obese: ≥30 kg/m2], waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) using Cox proportional hazards models.<br><b>Results</b>: Among men, a BMI < 22.5 kg/m2 was associated with higher head and neck cancer risk [HR 1.62; 95% confidence interval (CI), 1.23–2.12)]; BMI was not associated with head and neck cancer among women. WC and WHR were associated with greater risk of head and neck cancer among women (WC per 5 cm: HR, 1.08; 95% CI, 1.02–1.15; WHR per 0.1 unit: HR, 1.64; 95% CI, 1.38–1.93). After stratification by smoking status, the association for WHR was present only among smokers (Pinteraction = 0.004). Among men, WC and WHR were associated with head and neck cancer only upon additional adjustment for BMI (WC per 5 cm: HR 1.16; 95% CI, 1.07–1.26; WHR per 0.1 unit: HR, 1.42; 95% CI, 1.21–1.65).<br><b>Conclusions</b>: Central adiposity, particularly among women, may have a stronger association with head and neck cancer risk than previously estimated.<br><b>Impact</b>: Strategies to reduce obesity may beneficially impact head and neck cancer incidence.en_US
dc.descriptionPreprint. Published version available in <a href=http://dx.doi.org/10.1158/1055-9965.EPI-16-0886>Cancer Epidemiology, Biomarkers and Prevention, 26(6); 895–904</a>en_US
dc.identifier.citationWard, H.A., Wark, P.A., Muller, D.C., Steffen, A., Johansson, M., Norat, T., ... Riboli, E. Measured adiposity in relation to head and neck cancer risk in the European prospective investigation into cancer and nutrition. Cancer Epidemiology, Biomarkers and Prevention. 2017;26(6):895-904en_US
dc.identifier.cristinIDFRIDAID 1489602
dc.identifier.doi10.1158/1055-9965.EPI-16-0886
dc.identifier.issn1055-9965
dc.identifier.issn1538-7755
dc.identifier.urihttps://hdl.handle.net/10037/12076
dc.language.isoengen_US
dc.publisherAmerican Association for Cancer Researchen_US
dc.relation.journalCancer Epidemiology, Biomarkers and Prevention
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.titleMeasured adiposity in relation to head and neck cancer risk in the European prospective investigation into cancer and nutrition.en_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record