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dc.contributor.authorScelo, Ghislaine
dc.contributor.authorPurdue, Mark P.
dc.contributor.authorBrown, Kevin M.
dc.contributor.authorJohansson, Mattias
dc.contributor.authorWang, Zhaoming
dc.contributor.authorEckel-Passow, Jeanette E.
dc.contributor.authorYe, Yuanqing
dc.contributor.authorHofmann, Jonathan N.
dc.contributor.authorChoi, Jiyeon
dc.contributor.authorFoll, Matthieu
dc.contributor.authorGaborieau, Valerie
dc.contributor.authorMachiela, Mitchell J.
dc.contributor.authorColli, Leandro M.
dc.contributor.authorLi, Peng
dc.contributor.authorSampson, Joshua N.
dc.contributor.authorAbedi-Ardekani, Behnoush
dc.contributor.authorBesse, Celine
dc.contributor.authorBlanche, Helene
dc.contributor.authorBoland, Anne
dc.contributor.authorBurdette, Laurie
dc.contributor.authorChabrier, Amelie
dc.contributor.authorDurand, Geoffroy
dc.contributor.authorLe Calvez-Kelm, Florence
dc.contributor.authorProkhortchouk, Egor
dc.contributor.authorRobinot, Nivonirina
dc.contributor.authorSkryabin, Konstantin G.
dc.contributor.authorWozniak, Magdalena B.
dc.contributor.authorYeager, Meredith
dc.contributor.authorBasta-Jovanovic, Gordana
dc.contributor.authorDzamic, Zoran
dc.contributor.authorForetova, Lenka
dc.contributor.authorHolcatova, Ivana
dc.contributor.authorJanout, Vladimir
dc.contributor.authorMates, Dana
dc.contributor.authorMukeriya, Anush
dc.contributor.authorRascu, Stefan
dc.contributor.authorZaridze, David
dc.contributor.authorBencko, Vladimir
dc.contributor.authorCybulski, Cezary
dc.contributor.authorFabianova, Eleonora
dc.contributor.authorJinga, Viorel
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorLubinski, Jan
dc.contributor.authorNavratilova, Marie
dc.contributor.authorRudnai, Peter
dc.contributor.authorSzeszenia-Dabrowska, Neonila
dc.contributor.authorBenhamou, Simone
dc.contributor.authorCancel-Tassin, Geraldine
dc.contributor.authorCussenot, Olivier
dc.contributor.authorBaglietto, Laura
dc.contributor.authorBoeing, Heiner
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorLjungberg, Börje
dc.contributor.authorSitaram, Raviprakash T.
dc.contributor.authorBruinsma, Fiona
dc.contributor.authorJordan, Susan J.
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorWinship, Ingrid
dc.contributor.authorHveem, Kristian
dc.contributor.authorVatten, Lars Johan
dc.contributor.authorFletcher, Tony
dc.contributor.authorKoppova, Kvetoslava
dc.contributor.authorLarsson, Susanna C.
dc.contributor.authorWolk, Alicja
dc.contributor.authorBanks, Rosamonde E.
dc.contributor.authorSelby, Peter J.
dc.contributor.authorEaston, Douglas F.
dc.contributor.authorPharoah, Paul
dc.contributor.authorAndreotti, Gabriella
dc.contributor.authorFreeman, Laura E Beane
dc.contributor.authorKoutros, Stella
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorMännistö, Satu
dc.contributor.authorWeinstein, Stephanie
dc.contributor.authorClark, Peter E.
dc.contributor.authorEdwards, Todd L.
dc.contributor.authorLipworth, Loren
dc.contributor.authorGapstur, Susan M.
dc.contributor.authorStevens, Victoria L.
dc.contributor.authorCarol, Hallie
dc.contributor.authorFreedman, Matthew L.
dc.contributor.authorPomerantz, Mark M.
dc.contributor.authorCho, Eunyoung
dc.contributor.authorKraft, Peter
dc.contributor.authorPreston, Mark A.
dc.contributor.authorWilson, Kathryn M.
dc.contributor.authorGaziano, J. Michael
dc.contributor.authorSesso, Howard D.
dc.contributor.authorBlack, Amanda
dc.contributor.authorFreedman, Neal D.
dc.contributor.authorHuang, Wen-Yi
dc.contributor.authorAnema, John G.
dc.contributor.authorKahnoski, Richard J.
dc.contributor.authorLane, Brian R.
dc.contributor.authorNoyes, Sabrina L.
dc.contributor.authorPetillo, David
dc.contributor.authorTeh, Bin Tean
dc.contributor.authorPeters, Ulrike
dc.contributor.authorWhite, Emily
dc.contributor.authorAnderson, Garnet L.
dc.contributor.authorJohnson, Lisa
dc.contributor.authorLuo, Juhua
dc.contributor.authorBuring, Julie
dc.contributor.authorLee, I-Min
dc.contributor.authorChow, Wong-Ho
dc.contributor.authorMoore, Lee E.
dc.contributor.authorWood, Christopher
dc.contributor.authorEisen, Timothy
dc.contributor.authorHenrion, Marc
dc.contributor.authorLarkin, James
dc.contributor.authorBarman, Poulami
dc.contributor.authorLeibovich, Bradley C.
dc.contributor.authorChoueiri, Toni K.
dc.contributor.authorLathrop, G. Mark
dc.contributor.authorRothman, Nathaniel
dc.contributor.authorDeleuze, Jean-Francois
dc.contributor.authorMcKay, James D.
dc.contributor.authorParker, Alexander S.
dc.contributor.authorWu, Xifeng
dc.contributor.authorHoulston, Richard S.
dc.contributor.authorBrennan, Paul
dc.contributor.authorChanock, Stephen J.
dc.date.accessioned2018-02-09T14:26:46Z
dc.date.available2018-02-09T14:26:46Z
dc.date.issued2017-06-09
dc.description.abstractPrevious genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10−10), 3p22.1 (rs67311347, P=2.5 × 10−8), 3q26.2 (rs10936602, P=8.8 × 10−9), 8p21.3 (rs2241261, P=5.8 × 10−9), 10q24.33-q25.1 (rs11813268, P=3.9 × 10−8), 11q22.3 (rs74911261, P=2.1 × 10−10) and 14q24.2 (rs4903064, P=2.2 × 10−24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.en_US
dc.identifier.citationScelo, G., Purdue, M.P., Brown, K.M., Johansson, M., Wang, Z., Eckel-Passow, J.E., ... Chanock SJ. Genome-wide association study identifies multiple risk loci for renal cell carcinoma. Nature Communications. 2017;8:15724:1-9en_US
dc.identifier.cristinIDFRIDAID 1530401
dc.identifier.doi10.1038/ncomms15724
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/10037/12122
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.relation.journalNature Communications
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.titleGenome-wide association study identifies multiple risk loci for renal cell carcinomaen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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