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dc.contributor.authorNordby, Yngve
dc.contributor.authorRichardsen, Elin
dc.contributor.authorNess, Nora
dc.contributor.authorDønnem, Tom
dc.contributor.authorPatel, Hitendra R.H.
dc.contributor.authorBusund, Lill-Tove
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorAndersen, Sigve
dc.date.accessioned2018-03-05T13:13:36Z
dc.date.available2018-03-05T13:13:36Z
dc.date.issued2017-11-24
dc.description.abstractDue to insufficient prognostic tools, failure to predict aggressive prostate cancer (PC) has left patient selection for radical treatment an unsolved challenge. This has resulted in overtreatment with radical therapy. Better prognostic tools are urgently warranted. MicroRNAs (miRs) have emerged as important regulators of cellular pathways, resulting in altered gene expressions. miR-205 has previously been observed downregulated in PC, acting as tumor suppressor. Herein, the expression of miR-205 in prostate tissue was examined in a large, well-described cohort of 535 Norwegian prostatectomy patients. Using in situ hybridization, miR-205 expression was semiquantatively measured in normal and tumor tissues from radical prostatectomy specimens. Associations with clinicopathological data and PC relapse were calculated. Expression of miR-205 was lower in tumor epithelium compared to normal epithelium. No association was observed between miR-205 expression in primary tumor epithelium and cancer relapse. In contrast, high expression of miR-205 in normal epithelium was independently associated with biochemical relapse (HR = 1.64, p = 0.003). A prognostic importance of miR-205 expression was only found in the normal epithelium, raising the hypothesis of epithelial crosstalk between normal and tumor epithelium in PC. This finding supports the proposed novel hypothesis of an anti-cancerogenous function of normal epithelium in tumor tissue.en_US
dc.descriptionSource at <a href=https://doi.org/10.1038/s41598-017-16556-2> https://doi.org/10.1038/s41598-017-16556-2 </a>.en_US
dc.identifier.citationNordby, Y., Richardsen, E., Ness, N., Dønnem, T., Patel, H.R., Busund, L.T. ... Andersen, S. (2017). High miR-205 expression in normal epithelium is associated with biochemical failure - An argument for epithelial crosstalk in prostate cancer?. Scientific Reports. 7:16308.en_US
dc.identifier.issn2045-2322
dc.identifier.otherFRIDAID 1530453
dc.identifier.other10.1038/s41598-017-16556-2
dc.identifier.urihttps://hdl.handle.net/10037/12250
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.subjectmiRNAsen_US
dc.subjectPrognostic markersen_US
dc.subjectProstateen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.titleHigh miR-205 expression in normal epithelium is associated with biochemical failure - An argument for epithelial crosstalk in prostate cancer?en_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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