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dc.contributor.authorNæsgaard, Patrycja
dc.contributor.authorGrundt, Heidi
dc.contributor.authorNordøy, Arne
dc.contributor.authorStaines, Harry
dc.contributor.authorNilsen, Dennis W.T.
dc.date.accessioned2018-03-06T11:47:51Z
dc.date.available2018-03-06T11:47:51Z
dc.date.issued2017-07-24
dc.description.abstractBackground: <br> Fish is the natural dietary source of vitamin D. Reports on the influence of purified omega-3 fatty acids on its uptake are scarce. <br> Objectives: <br> We investigated the impact of a purified high-dose omega-3 compound compared to corn oil on 25-hydroxyvitamin D [25(OH)D] levels following an acute myocardial infarction. <br> Methods: <br> 228 patients were randomized 1:1 to receive a daily dose of either 4 g omega-3 (OMACOR®) or an equal dose of corn oil, administered double-blindly for 12 months. Total omega-3 and omega-6 measurements were available in 40 randomly picked patients. <br> Results: <br> There was no significant intergroup difference in 25(OH)D changes at 12 months follow-up (p = 0.12), but there was a minor statistical significant intragroup increase in 25(OH)D in both intervention arms (p < 0.001 for n-3 polyunsaturated fatty acids and p = 0.013 for corn oil, respectively). A positive correlation was noted between 25(OH)D and omega-3 prior to inclusion; r = 0.418, p = 0.007, attenuated at 12 months by purified omega-3 intervention; r = 0.021, p = 0.93. No positive correlation was observed between omega-6 and 25(OH)D. <br> Conclusion: <br> Long-term treatment with a high dose of purified omega-3 as compared to corn oil did not improve serum concentrations of vitamin D.en_US
dc.description.sponsorshipHelse Stavanger HF: ?en_US
dc.description<a href=https://doi.org/10.3389/fcvm.2017.00041> https://doi.org/10.3389/fcvm.2017.00041 </a>en_US
dc.identifier.citationNæsgaard, P., Grundt, H., Nordøy, A., Staines, H. & Nilsen, D. W. T. (2017) Vitamin D Uptake in Patients Treated with a High-Dosed Purified Omega-3 Compound in a Randomized Clinical Trial Following an Acute Myocardial Infarction. Frontiers in Cardiovascular Medicine, 4. 1-6. https://doi.org/10.3389/fcvm.2017.00041en_US
dc.identifier.cristinIDFRIDAID 1515664
dc.identifier.doi10.3389/fcvm.2017.00041
dc.identifier.issn2297-055X
dc.identifier.urihttps://hdl.handle.net/10037/12263
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Cardiovascular Medicine
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectVDP::Midical sciences: 700::Clinical medical sciences: 750::Cardiology: 771en_US
dc.subjectPrognose / Prognosisen_US
dc.titleVitamin D Uptake in Patients Treated with a High-Dosed Purified Omega-3 Compound in a Randomized Clinical Trial Following an Acute Myocardial Infarction.en_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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