Show simple item record

dc.contributor.authorMolina-Montes, Esther
dc.contributor.authorSánchez, María-José
dc.contributor.authorBuckland, Genevieve
dc.contributor.authorBueno-De-Mesquita, Hendrik Bastiaan
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorAmiano, Pilar
dc.contributor.authorWark, Petra A.
dc.contributor.authorKühn, Tilman
dc.contributor.authorKatzke, Verena
dc.contributor.authorHuerta, José María
dc.contributor.authorArdanaz, Eva
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorAffret, Aurelie
dc.contributor.authorHis, Mathilde
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorYe, Weimin
dc.contributor.authorSund, Malin
dc.contributor.authorBoeing, Heiner
dc.contributor.authorIqbal, Khalid
dc.contributor.authorOhlsson, Bodil
dc.contributor.authorSonestedt, Emily
dc.contributor.authorTjønneland, Anne
dc.contributor.authorPetersen, Kristina E.N.
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorSkeie, Guri
dc.contributor.authorAgnoli, Claudia
dc.contributor.authorPanico, Salvatore
dc.contributor.authorPalli, Domenico
dc.contributor.authorTumino, Rosario
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorFreisling, Heinz
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorOvervad, Kim
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorBamia, Christina
dc.contributor.authorVasilopoulou, Effie
dc.contributor.authorWareham, Nick
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorCross, Amanda J.
dc.contributor.authorWard, Heather A.
dc.contributor.authorRiboli, Elio
dc.contributor.authorDuell, Eric J.
dc.date.accessioned2018-03-13T08:44:47Z
dc.date.available2018-03-13T08:44:47Z
dc.date.issued2017-02-07
dc.description.abstractBackground: The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. <br>Methods: Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs). <br>Results: Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence¼0.99; 95% CI: 0.77–1.26, and HR per increments of two units in adherence to arMED¼1.00; 95% CI: 0.94–1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern. <br>Conclusions: A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.en_US
dc.descriptionSource at <a href=http://doi.org/10.1038/bjc.2017.14> http://doi.org/10.1038/bjc.2017.14 British Journal of Cancer 2017, 116:811–820</a>en_US
dc.identifier.citationMolina-Montes, E., Sánchez, M., Buckland, G., Bueno-De-Mesquita, H. B., Weiderpass, E., Amiano, P. ... Duell, E. J. (2017). Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort. British Journal of Cancer. 116(6):811-820.en_US
dc.identifier.issn0007-0920
dc.identifier.issn1532-1827
dc.identifier.otherFRIDAID 1489629
dc.identifier.other10.1038/bjc.2017.14
dc.identifier.urihttps://hdl.handle.net/10037/12301
dc.language.isoengen_US
dc.publisherCancer Research UKen_US
dc.relation.journalBritish Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleMediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohorten_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record