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dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorAppleby, Paul N.
dc.contributor.authorTipper, Sarah
dc.contributor.authorKey, Timothy J.
dc.contributor.authorAllen, Naomi E.
dc.contributor.authorNieters, Alexandra
dc.contributor.authorVermeulen, Roel
dc.contributor.authorRoulland, Sandrine
dc.contributor.authorCasabonne, Delphine
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorFortner, Renée T.
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLa Vecchia, Carlo
dc.contributor.authorKlinaki, Eleni
dc.contributor.authorHansen, Louise
dc.contributor.authorTjønneland, Anne
dc.contributor.authorBonnet, Fabrice
dc.contributor.authorFagherazzi, Guy
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorPala, Valeria
dc.contributor.authorMasala, Giovanna
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorBueno-De-Mesquita, Hendrik Bastiaan
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorQuirós, J. Ramón
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorGavrila, Diana
dc.contributor.authorAgudo, Antonio
dc.contributor.authorBorgquist, Signe
dc.contributor.authorRosendahl, Ann H.
dc.contributor.authorMelin, Beatrice
dc.contributor.authorWareham, Nick
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorGunter, Marc
dc.contributor.authorRiboli, Elio
dc.contributor.authorVineis, Paolo
dc.contributor.authorTravis, Ruth C.
dc.date.accessioned2018-03-13T11:13:49Z
dc.date.available2018-03-13T11:13:49Z
dc.date.issued2016-12-27
dc.description.abstractInsulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case–control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third = 0.77 [95% CI = 0.57–1.03], p<sub>trend</sub> = 0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (p<sub>heterogeneity for all</sub> ≥ 0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF-I concentrations with lymphoma subtypes.en_US
dc.descriptionSource at <a href=http://doi.org/10.1002/ijc.30528> Int. J. Cancer: 140, 1111–1118 (2017). http://doi.org/10.1002/ijc.30528 </a>.en_US
dc.identifier.citationPerez-Cornago, A., Appleby, P. N., Tipper, S., Key, T. J., Allen, N. E., Nieters, A. ... Travis, R. C. (2017). Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer. 140(5):1111-1118en_US
dc.identifier.cristinIDFRIDAID 1473228
dc.identifier.doi10.1002/ijc.30528
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttps://hdl.handle.net/10037/12309
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/232997/EU/TRANSCRIPTOMICS IN CANCER EPIDEMIOLOGY/TICE/en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectnested case–controlen_US
dc.subjectEPIC cohorten_US
dc.subjectIGF-Ien_US
dc.subjectplasmaen_US
dc.subjectnon-Hodgkin lymphomaen_US
dc.subjectlymphomaen_US
dc.subjectprospectiveen_US
dc.titlePrediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutritionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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