Stability of analgesic admixtures. Degradation and compatibility of common compounds in singular and binary admixtures in use for palliative treatment
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https://hdl.handle.net/10037/12338Date
2017-05-15Type
Master thesisMastergradsoppgave
Author
Koveland, Anne ChristineAbstract
Analgesic admixtures are given subcutaneously using patient-controlled analgesia devices and are often used in palliative care. The admixtures contain in most cases several compounds to treat multiple conditions. Despite the wide use, there are few data on the physical and chemical stability of the different admixtures. In this preliminary study, we investigated the stability and compatibility of common compounds in singular and binary admixtures diluted in 0.9 % NaCl: morphine, oxycodone, hydromorphone, midazolam and haloperidol in low and high concentrations. All admixtures were prepared aseptically, and the assays were done with HPLC-UV.
Publisher
UiT Norges arktiske universitetUiT The Arctic University of Norway
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Copyright 2017 The Author(s)
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