Compound screening in biological assays and subsequent optimization of hits is indispensable for the development of new molecular research tools and drug candidates. To facilitate such discoveries, the European Research Infrastructure EU-OPENSCREEN was founded recently with the support of its member countries and the European Commission. Its distributed character harnesses complementary knowledge, ...

The aim of this study was to evaluate histologic post-mortem autolytic changes in farmed Atlantic salmon. The fish were either stored at room temperature (RT, 21°C), refrigerated (4°C) or frozen (−20°C), while fish necropsy was performed at 0, 1, 4, 24 and 48 h post-storage (hps). In addition, gills were sampled at 0, 5, 10, 15, 30 and 45 min post-storage (mps) at room temperature (RT). The haematoxylin ...

In the present study the impact on gut microbiology and indigenous gut histology of Atlantic salmon (Salmo salar L.) was investigated following feeding of a control and a prebiotic (EWOS prebiosal®) diet and ex vivo exposure to saline or the probiotic bacterium Carnobacterium divergens. The results showed that ex vivo exposure of C. divergens at 108 CFU ml-1 did not cause cell damage to the intestine ...

Oppdrett av steril laks vil kunne redusere de negative interaksjonene mellom rømt oppdrettslaks og villaks, og dessuten forbedre fiskens velferd og kvalitet. Prosjektets hovedmål har vært å evaluere viktige produksjonsegenskaper hos steril laks etter å ha fjernet de embryonale kimcellene. Inaktivering av kimcellefaktoren Deadend ga livsvarig tap av kjønnsceller hos både hann- og hunnfisk. Steril ...

Controlling the expansion of capture capacity has been a major challenge for the fisheries management systems around the North Atlantic. Despite focused attempts to reduce this capacity in recent years in different jurisdictions, it has continued to expand. This chapter uses a case study of changes in Norwegian fisheries to help explain why this has happened. The article supports the replacement of ...

Seaweeds contain a wide range of secondary metabolites which serve multiple functions, including chemical and ecological mediation with microorganisms. Moreover, owing to their diverse bioactivity, including their antibiotic properties, they show potential for human use. Nonetheless, the chemical ecology of seaweeds is not equally understood across different regions; for example, Antarctic seaweeds ...

The extension of market systems and economic appraisal methods to the natural world and allocation of scarce resources is highly controversial and viewed by some as unethical. This has resulted in questions about the appropriate role of valuation and appraisal methods in informing policy and decision-making. We address this issue by assessing the different points of view that exist in marine research, ...

Antimicrobial peptides (AMPs) play a crucial role in innate immunity. We have previously reported the isolation and characterization of the AMPs, strongylocins 1 and 2, and centrocin 1, from coelomocyte extracts of Strongylocentrotus droebachiensis. Here we show that these AMPs were expressed in phagocytes. In addition, transcripts of strongylocin 1 were detected in vibratile cells and/or colorless ...

Background. Although, presence of tannase-producing and/or tannin tolerant gut bacteria has been documented in ruminants and non-ruminant herbivores, the topic is rarely addressed in fi sh. The present study aimed at enumeration of autochthonous tannase-producing bacteria in the gut of freshwater teleosts. <p> Materials and methods. This study covered seven freshwater teleost fi sh species: rohu, ...

Periods of fasting occur for a multitude of reasons in Atlantic salmon aquaculture. Feed withdrawal is widely used prior to transport, parasite treatments, preslaughter and for depuration purposes in recirculating aquaculture systems. Voluntary fasting is a coping response when fish have poor health or are exposed to poor farm environments. Owing to increased attention to animal welfare in aquaculture, ...