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Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortium

Permanent link
https://hdl.handle.net/10037/12534
DOI
https://doi.org/10.1007/s10552-017-0852-8
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Accepted manuscript version (PDF)
Date
2017-02-16
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Ose, Jennifer; Schock, Helena; Poole, Elizabeth M.; Lehtinen, Matti; Visvanathan, Kala; Helzlsouer, Kathy; Buring, Julie E.; Lee, I-Min; Tjønneland, Anne; Boutron-Ruault, Marie-Christine; Trichopoulou, Antonia; Mattiello, Amalia; Onland-Moret, N. Charlotte; Weiderpass, Elisabete; Sánchez, María-José; Idahl, Annika; Travis, Ruth C.; Rinaldi, Sabina; Merritt, Melissa A.; Wentzensen, Nicolas; Tworoger, Shelley S.; Kaaks, Rudolf; Fortner, Renée T.
Abstract
Purpose:
Biologic evidence suggests that the Insulin-like growth factor (IGF)-family may be involved in the etiology of epithelial invasive ovarian cancer (EOC). However, prospective studies investigating the role of IGF-I in ovarian carcinogenesis have yielded conflicting results.
Methods:
We pooled and harmonized data from 6 case-control studies nested within the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis IGFI concentrations and subsequent risk of EOC. We evaluated IGF-I concentrations and risk of EOC overall and by tumor subtype (defined by histology, grade, stage) in 1,270 cases and 2,907 matched controls. Multivariable conditional logistic regression models were used to calculate Odds Ratios (OR) and 95% Confidence Intervals (CI).
Results:
Doubling of IGF-I concentration was associated with significantly lower risk of overall EOC [ORlog2=0.82; CI: 0.72-0.93]. We observed no heterogeneity by tumor characteristics (e.g., histology, phet=0.62), menopausal status at blood collection (phet=0.79), or age at diagnosis (phet=0.60).
Conclusions:
These results suggest that IGF-I concentrations are inversely associated with EOC risk, independent of histological phenotype. Future prospective research should consider potential mechanisms for this association, including considering other members of the IGFfamily to better characterize the role of IGF-signaling in the etiology of EOC.
Description
This is a post-peer-review, pre-copyedit version of an article published in Cancer Causes and Control. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10552-017-0852-8
Publisher
Springer Verlag
Citation
Ose, J., Schock, H., Poole, E. M., Lehtinen, M., Visvanathan, K., Helzlsouer, K., ... Fortner, R. T. (2017). Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortium. Cancer Causes and Control, 28(5), 429-435. http://dx.doi.org/10.1007/s10552-017-0852-8
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