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dc.contributor.authorOse, Jennifer
dc.contributor.authorSchock, Helena
dc.contributor.authorPoole, Elizabeth M.
dc.contributor.authorLehtinen, Matti
dc.contributor.authorVisvanathan, Kala
dc.contributor.authorHelzlsouer, Kathy
dc.contributor.authorBuring, Julie E.
dc.contributor.authorLee, I-Min
dc.contributor.authorTjønneland, Anne
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorMattiello, Amalia
dc.contributor.authorOnland-Moret, N. Charlotte
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorSánchez, María-José
dc.contributor.authorIdahl, Annika
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorMerritt, Melissa A.
dc.contributor.authorWentzensen, Nicolas
dc.contributor.authorTworoger, Shelley S.
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorFortner, Renée T.
dc.date.accessioned2018-04-17T10:48:44Z
dc.date.available2018-04-17T10:48:44Z
dc.date.issued2017-02-16
dc.description.abstractPurpose: <br>Biologic evidence suggests that the Insulin-like growth factor (IGF)-family may be involved in the etiology of epithelial invasive ovarian cancer (EOC). However, prospective studies investigating the role of IGF-I in ovarian carcinogenesis have yielded conflicting results.<br> Methods: <br>We pooled and harmonized data from 6 case-control studies nested within the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis IGFI concentrations and subsequent risk of EOC. We evaluated IGF-I concentrations and risk of EOC overall and by tumor subtype (defined by histology, grade, stage) in 1,270 cases and 2,907 matched controls. Multivariable conditional logistic regression models were used to calculate Odds Ratios (OR) and 95% Confidence Intervals (CI). <br> Results: <br>Doubling of IGF-I concentration was associated with significantly lower risk of overall EOC [ORlog2=0.82; CI: 0.72-0.93]. We observed no heterogeneity by tumor characteristics (e.g., histology, phet=0.62), menopausal status at blood collection (phet=0.79), or age at diagnosis (phet=0.60).<br> Conclusions:<br> These results suggest that IGF-I concentrations are inversely associated with EOC risk, independent of histological phenotype. Future prospective research should consider potential mechanisms for this association, including considering other members of the IGFfamily to better characterize the role of IGF-signaling in the etiology of EOC.en_US
dc.description.sponsorshipDepartment of Defense Ovarian Cancer Research Program Grant No. W81XWH-12-1-0561; European Commission (DG-SANCO) and the International Agency for Research on Cancer; Danish Cancer Society; Ligue Contre le Cancer; Institut Gustave Roussy; Mutuelle Générale de l’Education Nationale; Institut National de la Santé et de la Recherche Médicale (INSERM); German Cancer Aid; German Cancer Research Center (DKFZ); Federal Ministry of Education and Research (BMBF); Deutsche Krebshilfe; Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research; The Hellenic Health Foundation; Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council; Dutch Ministry of Public Health, Welfare and Sports (VWS); Netherlands Cancer Registry (NKR); LK Research Funds; Dutch Prevention Funds; Dutch ZON (Zorg Onderzoek Nederland); World Cancer Research Fund (WCRF); Statistics Netherlands (The Netherlands); ERC-2009-AdG 232997 Nordforsk, Nordic Centreof Excellence programme on Food, Nutrition and Health (Norway); Health Research Fund (FIS), PI13/00061 to Granada; PI13/01162 to EPIC-Murcia); Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, ISCIII RETIC (RD06/0020) (Spain); Swedish Cancer Society; Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford); Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (United Kingdom). National Institutes of Health/NCI grants: R01 CA120061 (Finnish Maternity Cohort); UM1 CA186107, P01 CA87969, UM1 CA176726, R01 CA67262 (Nurses’ Health Study, Nurses’ Health Study II); HL043851, HL080467 HL099355 (Women’s Health Study). CLUEII was supported by National Cancer Institute grant numbers: CA-97857, CA-86308; Grant sponsor: M. Jean Goutal (donation): Grant sponsors: The Woodrow Wilson Foundation/Johnson and Johnson, The Lloyds TSB Charitable Foundation for the Channel Islands. RT Fortner was supported by a Marie Curie International Incoming Fellowship of the European Commission’s Seventh Framework Programme (MC-IIF-623984)en_US
dc.descriptionThis is a post-peer-review, pre-copyedit version of an article published in Cancer Causes and Control. The final authenticated version is available online at: <a href=http://dx.doi.org/10.1007/s10552-017-0852-8> http://dx.doi.org/10.1007/s10552-017-0852-8 </a>en_US
dc.identifier.citationOse, J., Schock, H., Poole, E. M., Lehtinen, M., Visvanathan, K., Helzlsouer, K., ... Fortner, R. T. (2017). Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortium. Cancer Causes and Control, 28(5), 429-435. http://dx.doi.org/10.1007/s10552-017-0852-8en_US
dc.identifier.issn0957-5243
dc.identifier.issn1573-7225
dc.identifier.otherFRIDAID 1464796
dc.identifier.other10.1007/s10552-017-0852-8
dc.identifier.urihttps://hdl.handle.net/10037/12534
dc.language.isoengen_US
dc.publisherSpringer Verlagen_US
dc.relation.journalCancer Causes and Control
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.titlePre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortiumen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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