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dc.contributor.authorSigurdardottir, Solrun
dc.contributor.authorAndelic, Nada
dc.contributor.authorWehling, Eike
dc.contributor.authorRøe, Cecilie
dc.contributor.authorAnke, Audny
dc.contributor.authorSkandsen, Toril
dc.contributor.authorHolthe, Øyvor
dc.contributor.authorJerstad, Tone
dc.contributor.authorAslaksen, Per Matti
dc.contributor.authorSchanke, Anne-Kristine
dc.date.accessioned2018-06-22T09:21:11Z
dc.date.available2018-06-22T09:21:11Z
dc.date.issued2015
dc.description.abstractObjectives: To determine the rates of cognitive impairment 1 year after severe traumatic brain injury (TBI) and to examine the influence of demographic, injury severity, rehabilitation, and subacute functional outcomes on cognitive outcomes 1 year after severe TBI.<p> Setting: National multicenter cohort study over 2 years.<p> Participants: Patients (N = 105), aged 16 years or older, with Glasgow Coma Scale score of 3 to 8 and Galveston Orientation and Amnesia Test score of more than 75.<p> Main Measures : Neuropsychological tests representing cognitive domains of Executive Functions, Processing Speed, and Memory. Injury severity included Rotterdam computed tomography score, Glasgow Coma Scale score, and posttraumatic amnesia (PTA) duration, together with length of rehabilitation and Glasgow Outcome Scale–Extended score.<p> Results: In total, 67% of patients with severe TBI had cognitive impairment. Executive Functions, Processing Speed, and Memory were impaired in 41%, 58%, and 57% of patients, respectively. Using multiple regression analysis, Processing Speed was significantly related to PTA duration, Glasgow Outcome Scale–Extended score, and length of inpatient rehabilitation (R 2 = 0.30); Memory was significantly related to Glasgow Outcome Scale–Extended score (R 2 = 0.15); and Executive Functions to PTA duration (R 2 = 0.10). Rotterdam computed tomography and Glasgow Coma Scale scores were not associated with cognitive functioning at 1 year postinjury.<p> Conclusion: Findings highlight cognitive consequences of severe TBI, with nearly two-thirds of patients showing cognitive impairments in at least 1 of 3 cognitive domains. Regarding injury severity predictors, only PTA duration was related to cognitive functioning.en_US
dc.description.sponsorshipHelseforetak: Sunnaas sykehus HFen_US
dc.descriptionAccepted manuscript version. Published version available in <a href=http://doi.org/10.1097/HTR.0000000000000039> The journal of head trauma rehabilitation (2015) 30(2), p. E1-E12. </a>en_US
dc.identifier.citationSigurdardottir, S., Andelic, N., Wehling, E.I., Røe, C., Anke, A., Skandsen, T., ... Schanke, A. (2015). Neuropsychological functioning in a national cohort of severe traumatic brain injury: demographic and acute injury-related predictors. The journal of head trauma rehabilitation. 30(2), E1-E12.en_US
dc.identifier.cristinIDFRIDAID 1127752
dc.identifier.doi10.1097/HTR.0000000000000039
dc.identifier.issn0885-9701
dc.identifier.issn1550-509X
dc.identifier.urihttps://hdl.handle.net/10037/12960
dc.language.isoengen_US
dc.publisherLippincott, Williams & Wilkinsen_US
dc.relation.journalThe journal of head trauma rehabilitation
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/HELSEVEL/209748/Norway/Application for a Research Centre for Habilitation and Rehabilitation Models and Services/CHARM/en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Fysikalsk medisin og rehabilitering: 764en_US
dc.subjectVDP::Midical sciences: 700::Clinical medical sciences: 750::Physical medicine and rehabilitation: 764en_US
dc.subjectVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Traumatologi: 783en_US
dc.subjectVDP::Midical sciences: 700::Clinical medical sciences: 750::Traumatology: 783en_US
dc.subjectcognitive impairmenten_US
dc.subjectexecutive functionsen_US
dc.subjectmemoryen_US
dc.subjectoutcome predictionen_US
dc.subjecttraumatic brain injuryen_US
dc.titleNeuropsychological functioning in a national cohort of severe traumatic brain injury: demographic and acute injury-related predictorsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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