Successful treatment of skin infections requires eradication of biofilms found in up to 90 % of all chronic wounds, causing delayed healing and increased morbidity. We hypothesized that chitosan hydrogel boosts the activity of liposomally-associated membrane active antimicrobials (MAA) and could potentially improve bacterial and biofilm eradication. Therefore, liposomes (∼300 nm) bearing chlorhexidine ...

<i>Objective</i> - To validate self-reported use of medications for secondary prevention of coronary heart disease (CHD) in a population-based health study by comparing self-report with pharmacy dispensing data, and explore different methods for defining medication use in prescription databases.<br><br> <i>Study design and setting</i> - Self-reported medication use among participants with CHD ...

E-prescribing is now widespread and, in some countries, has completely replaced paper prescriptions. In Norway, almost all prescribing is electronic, except for multidose drug dispensing (MDD), which is still sent to the pharmacy by fax or ordinary mail. MDD is an adherence aid used by one-third of all patients receiving home care services. In this paper, we present results from a qualitative study ...

Introduction - An expected future increase in older adults will demand changes in health care delivery, making development, implementation and evaluation of new health care models essential. The rationale for political decision-making concerning the implementation and application of interventions in health care should include cost estimations, specifically those involving clinical interventions. To ...

Vitamin D is vital for calcium homeostasis and skeletal health, has immunomodulatory effects and is involved in the regulation of differentiation and proliferation of many different cell types. Adipose tissue is an important metabolic organ and a major organ for vitamin D storage. Though, the role of vitamin D and its function in adipose tissue is not fully explored. This thesis applies a solvent ...

Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption ...

Background The rapid increase in antimicrobial resistance (AMR) has become a major threat to the successful management of infectious diseases. To counteract this global threat, development of novel treatment strategies is essential. A promising strategy may be exploiting collateral sensitivity; a phenomenon that occurs when a microorganism that has developed resistance to one antimicrobial agent, ...

Vaginal infections are common in women of all ages and proper treatment is essential. The vaginal route of administration can be considered as favourable for the local therapy of vaginal infections. There are several vaginal dosage forms currently available; however, all suffer from limitations such as leakage and limited residence time at the site of action resulting in reduced therapeutic effect. ...

Etikkrådet for farmasøyter i Norge har en visjon om at alle farmasøyter skal være etisk reflekterte yrkesutøvere. Etiske dilemma oppstår når ulike verdier kommer i konflikt med hverandre og ikke kan forenes i en og samme handling. Apotekene i Norge har i de siste årene forandret seg i takt med nye lover og regler og farmasøytene har etter hvert fått utvidede oppgaver som setter andre krav til yrket. ...

<p>Bakgrunn: Rasjonell antibiotikaforskrivning, som i denne sammenheng vil si i henhold til Nasjonal faglig retningslinje for antibiotikabruk i sykehus, er et av de viktigste tiltakene vi har for å motvirke resistensutvikling. Forskrivning i henhold til retningslinjer er også assosiert med gunstige pasientutfall. Samfunnservervet pneumoni (community-acquired pneumonia; CAP) og kronisk obstruktiv ...