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dc.contributor.authorMayerhofer, Christiane Caroline
dc.contributor.authorUeland, Thor
dc.contributor.authorBroch, Kaspar
dc.contributor.authorVincent, Royce P.
dc.contributor.authorCross, Gemma F.
dc.contributor.authorDahl, Christen Peder
dc.contributor.authorAukrust, Pål
dc.contributor.authorGullestad, Lars
dc.contributor.authorHov, Johannes Espolin Roksund
dc.contributor.authorTrøseid, Marius
dc.date.accessioned2018-07-04T08:04:00Z
dc.date.available2018-07-04T08:04:00Z
dc.date.issued2017-09-09
dc.description.abstract<p><i>Objective</i> Bile acids (BAs) are now recognized as signaling molecules and emerging evidence suggests that BAs affect cardiovascular function. The gut microbiota has recently been linked to the severity of heart failure (HF), and microbial metabolism has a major impact on BA homeostasis. We aimed to investigate the pattern of BAs, and particularly microbiota-transformed (secondary) BAs, in patients with chronic HF.</p> <p><i>Methods and Results</i> This was a prospective, observational, single-center study including 142 patients with chronic HF and 20 age- and sex-matched healthy control subjects. We measured plasma levels of primary, secondary, and total BAs, and explored their associations with clinical characteristics and survival. Plasma levels of primary BAs were lower (P < .01) and the ratios of secondary to primary BAs higher (P < .001) in patients with HF compared with control subjects. Approximately 40% of patients in the upper tertile of the ratio of secondary to primary BAs died during 5.6 years of follow-up (unadjusted Cox regression: hazard ratio 1.93, 95% confidence interval 1.01–3.68, compared with the lower tertiles). However, this association was attenuated and no longer significant in multivariate analyses.</p> <p><i>Conclusions</i> Levels of primary BAs were reduced and specific secondary BAs increased in patients with chronic HF. This pattern was associated with reduced overall survival in univariate analysis, but not in multivariate analyses. Future studies should assess the regulation and potential role of BA metabolism in HF.en_US
dc.description.sponsorshipNorwegian Health Association (6782)en_US
dc.descriptionAccepted manuscript version. Published version available at <a href=https://doi.org/10.1016/j.cardfail.2017.06.007> https://doi.org/10.1016/j.cardfail.2017.06.007</a>.en_US
dc.identifier.citationMayerhofer, C.C., Ueland, T., Broch, K., Vincent, R.P., Cross, G.F., ... Trøseid, M. (2017). Increased secondary/primary bile acid ratio in chronic heart failure. Journal of Cardiac Failure, 23(9), 666-671. https://doi.org/10.1016/j.cardfail.2017.06.007en_US
dc.identifier.cristinIDFRIDAID 1514342
dc.identifier.doi10.1016/j.cardfail.2017.06.007
dc.identifier.issn1071-9164
dc.identifier.issn1532-8414
dc.identifier.urihttps://hdl.handle.net/10037/13143
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of Cardiac Failure
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMEDBIO/240787/Norway/NORGUT: EXPLORING THE METABOLIC SIGNATURES OF DISEASE AND DRUG ASSOCIATED GENOMIC FEATURES OF THE GUT MICROBIOTA IN NORWAY//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750en_US
dc.subjectChronic heart failureen_US
dc.subjectgut microbiotaen_US
dc.subjectBile acids profileen_US
dc.subjectclinical outcomeen_US
dc.titleIncreased secondary/primary bile acid ratio in chronic heart failureen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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