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dc.contributor.authorVaysse, Charlotte
dc.contributor.authorLømo, Jon
dc.contributor.authorGarred, Øystein
dc.contributor.authorFjeldheim, Frøydis Nyborg
dc.contributor.authorLofterød, Trygve
dc.contributor.authorSchlichting, Ellen
dc.contributor.authorMcTiernan, Anne
dc.contributor.authorFrydenberg, Hanne
dc.contributor.authorHusøy, Anders
dc.contributor.authorLundgren, Steinar
dc.contributor.authorFagerland, Morten W
dc.contributor.authorRichardsen, Elin
dc.contributor.authorWist, Erik
dc.contributor.authorMuller, Catherine
dc.contributor.authorThune, Inger
dc.date.accessioned2018-08-16T11:52:50Z
dc.date.available2018-08-16T11:52:50Z
dc.date.issued2017-05-03
dc.description.abstractGrowing evidence indicates that adiposity is associated with breast cancer risk and negatively affects breast cancer recurrence and survival, a paracrine role of mammary adipose tissue being very likely in this process. In contrast to other adipose depots, occurrence of a sub-inflammatory state of mammary adipose tissue defined by dying adipocytes surrounded by macrophages forming crown-like structures in overweight and obese subjects, remains only partially described. In a general population of breast cancer patients (107 patients) mostly undergoing breast-conserving surgery, we found a positive association between patient’s body composition, breast adipocytes size, and presence of crown-like structures in mammary adipose tissue close to the tumor. Overweight (BMI: 25.0–29.9 kg/m<sup>2</sup>) and obese (BMI ≥ 30.0 kg/m<sup>2</sup>) patients have 3.2 and 6.9 times higher odds ratio of crown-like structures respectively, compared with normal weight patients. The relatively small increase in adipocyte size in crown-like structures positive vs. negative patients suggests that mammary adipose tissue inflammation might occur early during hypertrophy. Our results further highlight that body mass index is an adequate predictor of the presence of crown-like structures in mammary adipose tissue among postmenopausal women, whereas in premenopausal women truncal fat percentage might be more predictive, suggesting that mammary adipose tissue inflammation is more likely to occur in patients exhibiting visceral obesity. Finally, the presence of crown-like structures was positively associated with systemic markers such as the Triglyceride/High-density lipoprotein-cholesterol ratio serum C-reactive protein and glucose/(HbA1c) glycated Haemoglobin. These compelling results demonstrate that excess adiposity, even in overweight patients, is associated with mammary adipose tissue inflammation, an event that could contribute to breast cancer development and progression.en_US
dc.description.sponsorshipAssociation de Recherche contre le Cancer (ARC) Fondation Toulouse Cancer Santé Les Courbes du 31 Fondation Sisley-d’Ornano South-East Norwegian Health Authority Active Against Cancer-Gjensidige Stiftelsen INCA PL-2013-66en_US
dc.descriptionSource at <a href=https://doi.org/10.1038/s41523-017-0015-9> https://doi.org/10.1038/s41523-017-0015-9</a>. Accepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a>en_US
dc.identifier.citationVaysse, C., Lømo, J., Garred, Ø., Fjeldheim, F., Lofterød, T., Schlichting, E., ... Thune, I. (2017). Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer. NPJ breast cancer, 3(19). https://doi.org/10.1038/s41523-017-0015-9en_US
dc.identifier.cristinIDFRIDAID 1565110
dc.identifier.doi10.1038/s41523-017-0015-9
dc.identifier.issn2374-4677
dc.identifier.urihttps://hdl.handle.net/10037/13442
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.relation.journalNPJ breast cancer
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/KLINISK/213997/Norway/Insulin, lipids and Breast Cancer in a Randomised Clinical Trial. The Energy and Balance Aspects studies/EBBA I+II/en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.titleInflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast canceren_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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