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dc.contributor.authorPetrovic, Voin
dc.contributor.authorNepal, Anala
dc.contributor.authorOlaisen, Camilla
dc.contributor.authorBachke, Siri
dc.contributor.authorHira, Jonathan
dc.contributor.authorSøgaard, Caroline Krogh
dc.contributor.authorRøst, Lisa Marie
dc.contributor.authorMisund, Kristine
dc.contributor.authorAndreassen, Trygve
dc.contributor.authorMelø, Torun Margareta
dc.contributor.authorBartosova, Zdenka
dc.contributor.authorBruheim, Per
dc.contributor.authorOtterlei, Marit
dc.date.accessioned2018-08-24T08:00:12Z
dc.date.available2018-08-24T08:00:12Z
dc.date.issued2018-04-05
dc.description.abstractThe use of garlic and garlic-based extracts has been linked to decreased incidence of cancer in epidemiological studies. Here we examine the molecular and cellular activities of a simple homemade ethanol-based garlic extract (GE). We show that GE inhibits growth of several different cancer cells in vitro, as well as cancer growth in vivo in a syngeneic orthotopic breast cancer model. Multiple myeloma cells were found to be especially sensitive to GE. The GE was fractionated using solid-phase extractions, and we identified allicin in one GE fraction; however, growth inhibitory activities were found in several additional fractions. These activities were lost during freeze or vacuum drying, suggesting that the main anti-cancer compounds in GE are volatile. The anti-cancer activity was stable for more than six months in −20 °C. We found that GE enhanced the activities of chemotherapeutics, as well as MAPK and PI3K inhibitors. Furthermore, GE affected hundreds of proteins involved in cellular signalling, including changes in vital cell signalling cascades regulating proliferation, apoptosis, and the cellular redox balance. Our data indicate that the reduced proliferation of the cancer cells treated by GE is at least partly mediated by increased endoplasmic reticulum (ER) stress.en_US
dc.descriptionSource at <a href=https://doi.org/10.3390/nu10040450> https://doi.org/10.3390/nu10040450</a>. Accepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a>en_US
dc.identifier.citationPetrovic, V., Nepal, A., Olaisen, C., Bachke, S., Hira, J., Søgaard, C.K., ... Otterlei, M. (2018). Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress. Nutrients, 10(4). https://doi.org/10.3390/nu10040450en_US
dc.identifier.cristinIDFRIDAID 1579539
dc.identifier.doi10.3390/nu10040450
dc.identifier.issn2072-6643
dc.identifier.urihttps://hdl.handle.net/10037/13587
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalNutrients
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk molekylærbiologi: 711en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical molecular biology: 711en_US
dc.subjectapoptosisen_US
dc.subjectER stressen_US
dc.subjectallicinen_US
dc.subjectOrgano Sulfur Compounds (OSCs)en_US
dc.subjectkinomeen_US
dc.subjectcanceren_US
dc.titleAnti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stressen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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