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dc.contributor.authorPapadimitriou, Nikos
dc.contributor.authorTsilidis, Konstantinos K.
dc.contributor.authorOrfanos, Philippos
dc.contributor.authorBenetou, Vassiliki
dc.contributor.authorNtzani, Evangelia E.
dc.contributor.authorSoerjomataram, Isabelle
dc.contributor.authorKünn-Nelen, Annemarie
dc.contributor.authorPettersson-Kymmer, Ulrika
dc.contributor.authorEriksson, Sture
dc.contributor.authorBrenner, Hermann
dc.contributor.authorSchöttker, Ben
dc.contributor.authorSaum, Kai-Uwe
dc.contributor.authorHolleczek, Bernd
dc.contributor.authorGrodstein, Francine D.
dc.contributor.authorFeskanich, Diane
dc.contributor.authorOrsini, Nicola
dc.contributor.authorWolk, Alicja
dc.contributor.authorBellavia, Andrea
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorJørgensen, Lone
dc.contributor.authorBoffetta, Paolo
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorTrichopoulou, Antonia
dc.date.accessioned2018-09-06T11:01:01Z
dc.date.available2018-09-06T11:01:01Z
dc.date.issued2017-04-11
dc.description.abstract<p><i>Background</i>: No studies have estimated disability-adjusted life-years (DALYs) lost due to hip fractures using real-life follow-up cohort data. We aimed to quantify the burden of disease due to incident hip fracture using DALYs in prospective cohorts in the CHANCES consortium, and to calculate population attributable fractions based on DALYs for specific risk factors.</p> <p><i>Methods</i>: We used data from six cohorts of participants aged 50 years or older at recruitment to calculate DALYs. We applied disability weights proposed by the National Osteoporosis Foundation and did a series of sensitivity analyses to examine the robustness of DALY estimates. We calculated population attributable fractions for smoking, body-mass index (BMI), physical activity, alcohol intake, type 2 diabetes and parity, use of hormone replacement therapy, and oral contraceptives in women. We calculated summary risk estimates across cohorts with pooled analysis and random-effects meta-analysis methods.</p> <p><i>Findings</i>: 223 880 men and women were followed up for a mean of 13 years (SD 6). 7724 (3·5%) participants developed an incident hip fracture, of whom 413 (5·3%) died as a result. 5964 DALYs (27 per 1000 individuals) were lost due to hip fractures, 1230 (20·6%) of which were in the group aged 75–79 years. 4150 (69·6%) DALYs were attributed to disability. Current smoking was the risk factor responsible for the greatest hip fracture burden (7·5%, 95% CI 5·2–9·7) followed by physical inactivity (5·5%, 2·1–8·5), history of diabetes (2·8%, 2·1–4·0), and low to average BMI (2·0%, 1·4–2·7), whereas low alcohol consumption (0·01–2·5 g per day) and high BMI had a protective effect.</p> <p><i>Interpretation</i>: Hip fracture can lead to a substantial loss of healthy life-years in elderly people. National public health policies should be strengthened to reduce hip fracture incidence and mortality. Primary prevention measures should be strengthened to prevent falls, and reduce smoking and a sedentary lifestyle.en_US
dc.descriptionSource at <a href=https://doi.org/10.1016/S2468-2667(17)30046-4> https://doi.org/10.1016/S2468-2667(17)30046-4</a>.en_US
dc.identifier.citationPapadimitriou, N., Tsilidis, K.K., Orfanos, P., Benetou, V., Ntzani, E.E., Soerjomataram, I., ... Trichopoulou, A. (2017). Burden of hip fracture using disability-adjusted life-years: a pooled analysis of prospective cohorts in the CHANCES consortium. The Lancet Public Health, 2(5), e239-e246. https://doi.org/10.1016/S2468-2667(17)30046-4en_US
dc.identifier.cristinIDFRIDAID 1514799
dc.identifier.doi10.1016/S2468-2667(17)30046-4
dc.identifier.issn2468-2667
dc.identifier.urihttps://hdl.handle.net/10037/13698
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalThe Lancet Public Health
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-HEALTH/242244/EU/Consortium on Health and Ageing: Network of Cohorts in Europe and the United States/CHANCES/en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Ortopedisk kirurgi: 784en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Orthopedic surgery: 784en_US
dc.titleBurden of hip fracture using disability-adjusted life-years: a pooled analysis of prospective cohorts in the CHANCES consortiumen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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