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Isolation and Synthesis of Pulmonarins A and B, Acetylcholinesterase Inhibitors from the Colonial Ascidian Synoicum pulmonaria

Permanent link
https://hdl.handle.net/10037/13820
DOI
https://doi.org/10.1021/np401002s
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Accepted manuscript version (PDF)
Date
2014-02-14
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Tadesse, Margey; Svenson, Johan; Sepcič, Kristina; Trembleau, Laurent; Engqvist, Stig Olov Magnus; Andersen, Jeanette Hammer; Jaspars, Marcel; Stensvåg, Klara; Haug, Tor
Abstract
Pulmonarins A and B are two new dibrominated marine acetylcholinesterase inhibitors that were isolated and characterized from the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast. The structures of natural pulmonarins A and B were tentatively elucidated by spectroscopic methods and later verified by comparison with synthetically prepared material. Both pulmonarins A and B displayed reversible, noncompetitive acetylcholinesterase inhibition comparable to several known natural acetylcholinesterase inhibitiors. Pulmonarin B was the strongest inhibitor, with an inhibition constant (Ki) of 20 μM. In addition to reversible, noncompetitive acetylcholinesterase inhibition, the compounds displayed weak antibacterial activity but no cytotoxicity or other investigated bioactivities.
Description
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of natural products, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/np401002s.
Publisher
American Chemical Society
Citation
Tadesse, M., Svenson, J., Sepcič, K., Trembleau, L., Engqvist, M., Andersen, J.H., ... Haug, T. (2014). Isolation and Synthesis of Pulmonarins A and B, Acetylcholinesterase Inhibitors from the Colonial Ascidian Synoicum pulmonaria. Journal of natural products, 77(2), 364-369. https://doi.org/10.1021/np401002s
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