Blar i forfatter Artikler, rapporter og annet (farmasi) "Oteiza, Ana"

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    • Evaluation by metabolic profiling and in vitro autoradiography of two promising GnRH‐receptor ligands for brain SPECT imaging 

      Fjellaksel, Richard; Moldes-Anaya, Angel; Vasskog, Terje; Oteiza, Ana; Martin-Armas, Maria Montserrat; Hjelstuen, Ole Kristian; Hansen, Jørn H; Riss, Patrick; Sundset, Rune (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-18)
      The increased expression of gonadotropin releasing hormone receptor (GnRH‐R) in brain has been strongly linked to Alzheimer disease. Therefore, the development of radiolabeled imaging agents for GnRH‐R is relevant for early diagnosis of Alzheimer disease. We have recently disclosed the discovery of two promising compounds displaying nanomolar‐range affinity for the GnRH‐R. In the present study, a ...

    • First in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptor 

      Fjellaksel, Richard; Oteiza, Ana; Martin, armas maria montserrat; Riss, Patrick; Hjelstuen, Ole Kristian; Kuttner, Samuel; Hansen, Jørn H; Sundset, Rune (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-09)
      <p><i>Objectives</i>: In vivo evaluations of a gonadotropin releasing hormone-receptor single photon emission computed tomography radiotracer for non-invasive detection of gonadotropin releasing homone-receptors in brain.</p> <p><i>Results</i>: We have used a simple, robust and high-yielding procedure to radiolabel an alpha-halogenated bioactive compound with high radiochemical yield. Literature ...