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dc.contributor.authorLi, Chun
dc.contributor.authorBlencke, Hans-Matti
dc.contributor.authorHaug, Tor
dc.contributor.authorStensvåg, Klara
dc.date.accessioned2018-09-27T10:45:06Z
dc.date.available2018-09-27T10:45:06Z
dc.date.issued2014-11-06
dc.description.abstractAntimicrobial peptides (AMPs) are important effector molecules in innate immunity. Here we briefly summarize characteristic traits of AMPs and their mechanisms of antimicrobial activity. Echinoderms live in a microbe-rich marine environment and are known to express a wide range of AMPs. We address two novel AMP families from coelomocytes of sea urchins: cysteine-rich AMPs (strongylocins) and heterodimeric AMPs (centrocins). These peptide families have conserved preprosequences, are present in both adults and pluteus stage larvae, have potent antimicrobial properties, and therefore appear to be important innate immune effectors. Strongylocins have a unique cysteine pattern compared to other cysteine-rich peptides, which suggests a novel AMP folding pattern. Centrocins and SdStrongylocin 2 contain brominated tryptophan residues in their native form. This review also includes AMPs isolated from other echinoderms, such as holothuroidins, fragments of beta-thymosin, and fragments of lectin (CEL-III). Echinoderm AMPs are crucial molecules for the understanding of echinoderm immunity, and their potent antimicrobial activity makes them potential precursors of novel drug leads.en_US
dc.description.sponsorshipUiT The Arctic University of Norwayen_US
dc.descriptionAccepted manuscript version. Published version available at <a href=https://doi.org/10.1016/j.dci.2014.11.002> https://doi.org/10.1016/j.dci.2014.11.002</a>. Licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a>en_US
dc.identifier.citationLi, C., Blencke, H.-M., Haug, T. & Stensvåg, K. (2015). Antimicrobial peptides in echinoderm host defense. Developmental and Comparative Immunology, 49(1), 190-197. https://doi.org/10.1016/j.dci.2014.11.002en_US
dc.identifier.cristinIDFRIDAID 1172690
dc.identifier.doi10.1016/j.dci.2014.11.002
dc.identifier.issn0145-305X
dc.identifier.issn1879-0089
dc.identifier.urihttps://hdl.handle.net/10037/13875
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalDevelopmental and Comparative Immunology
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FUGE/208546/Norway/eXploring the BIOactive PEPtide Space of arctic marine invertebrates//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920en_US
dc.subjectVDP::Agriculture and fishery disciplines: 900::Fisheries science: 920en_US
dc.subjectEchinodermsen_US
dc.subjectCoelomocytesen_US
dc.subjectLarvaen_US
dc.subjectInnate immunityen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectMembrane integrityen_US
dc.titleAntimicrobial peptides in echinoderm host defenseen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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