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dc.contributor.authorTuri, Z
dc.contributor.authorBjørkedal, Espen
dc.contributor.authorGunkel, Luisa
dc.contributor.authorAntal, Andrea
dc.contributor.authorPaulus, Walter
dc.contributor.authorMittner, Matthias
dc.date.accessioned2018-12-06T11:47:57Z
dc.date.available2018-12-06T11:47:57Z
dc.date.issued2018-11-28
dc.description.abstractInactive interventions can have significant effects on cognitive performance. Understanding the generation of these cognitive placebo/nocebo effects is crucial for evaluating the cognitive impacts of interventional methods, such as non-invasive brain stimulation (NIBS). We report both cognitive placebo and nocebo effects on reward-based learning performance induced using an active sham NIBS protocol, verbal suggestions and conditioning in 80 healthy participants. Whereas our placebo manipulation increased both expected and perceived cognitive performance, nocebo had a detrimental effect on both. Model- based analysis suggests manipulation-specific strategic adjustments in learning-rates: Participants in the placebo group showed stronger learning from losses and reduced behavioral noise, whereas in the nocebo group stronger learning from gains and increased behavioral noise. We conclude that experimentally induced expectancy can impact cognitive functions of healthy adult participants. This has important implications for the use of double-blind study designs that can effectively maintain blinding in NIBS studies.en_US
dc.description.sponsorshipResearch Program, University Medical Center University of Goettingen The Research Fellowship by the Deutsche Forschungsgemeinschaf (DFG, German Research Foundation)en_US
dc.descriptionSource at <a href=https://doi.org/10.31234/osf.io/87kea> https://doi.org/10.31234/osf.io/87kea</a>.en_US
dc.identifier.citationTuri, Z., Bjørkedal, E., Gunkel, L., Antal, A., Paulus, W. & Mittner, M. (2018). Evidence for Cognitive Placebo and Nocebo Effects in Healthy Individuals. <i>Scientific Reports</i>, 8(17443). https://doi.org/10.31234/osf.io/87keaen_US
dc.identifier.issn2045-2322
dc.identifier.otherFRIDAID 1636342
dc.identifier.urihttps://hdl.handle.net/10037/14295
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752en_US
dc.titleEvidence for Cognitive Placebo and Nocebo Effects in Healthy Individualsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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