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  • CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state 

    Huijgens, Patty Thalia; Heijkoop, Roy; Vanderschuren, Louk; Lesscher, Heidi; Snoeren, Eelke Mirthe Simone (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-24)
    This study aims to investigate the underlying neurobiological mechanisms that regulate natural reward seeking behaviors, specifically in the context of sexual behavior and sucrose self-administration. The role of CaMKIIa+neurons in the bed nucleus of the stria terminalis (BNST) was explored using chemogenetic silencing and -stimulation. Additionally, the study examined how these effects ...
  • Poorer self-reported mental health and general health among first year upper secondary school students do not predict school dropout: a five-year prospective study 

    Goll, Charlotte Bjørnskov; Sørlie, Tore; Friborg, Oddgeir; Ottosen, Karl-Ottar; Sæle, Rannveig Grøm (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-08)
    Introduction: Education is important for socioeconomic, work and health status; thus, dropping out of secondary school is of major concern. In Norway, 1 out of 5 is dropping out from upper secondary education. Academic performance is a known predictor for dropout, but the role of mental and general health status is studied less.<p> <p>Methods: By use of student data collected during the first ...
  • Rapport - Workshop om fremtidens skredopplæring 

    Dassler, Tim; Skille, Tarjei Tveito; Pfuhl, Gerit; Fjellaksel, Richard (Research report; Forskningsrapport, 2023)
    2. november 2023 gjennomførte Norskred i samarbeid med Nortind, Den norske turistforeningen (DNT), Norsk fjellsportforum (NF) og UiT CARE – senter for snøskredforskning en workshop om fremtidens skredopplæring i Norge. Workshopen ble arrangert dagen før den nordiske skredkonferansen 2023 på Oppdal.<p> <p>Dagens modell for skredopplæring inneholder mange læringsmål og en kursstige som virker å ...
  • Medial Temporal Lobe Atrophy in Predementia Alzheimer's Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohort 

    Jarholm, Jonas Alexander; Bjørnerud, Atle; Dalaker, Turi Olene; Akhavi, Mehdi Sadat; Kirsebom, Bjørn-Eivind; Pålhaugen, Lene; Nordengen, Kaja; Grøntvedt, Gøril Rolfseng; Nakling, Arne Exner; Kalheim, Lisa Flem; Almdahl, Ina Selseth; Teceläo, Sandra Raquel Ramos; Fladby, Tormod; Selnes, Per (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-27)
    Background: Atrophy of the medial temporal lobe (MTL) is a biological characteristic of Alzheimer’s disease (AD) and can be measured by segmentation of magnetic resonance images (MRI). Objective: To assess the clinical utility of automated volumetry in a cognitively well-defined and biomarker-classified multi-center longitudinal predementia cohort. <p>Methods: We used Automatic Segmentation of ...
  • Because sex matters: The case of female sexual response 

    Ventura-Aquino, Elisa; Ågmo, Anders j (Chapter; Bokkapittel, 2023-05-17)
    In recent years, the Food and Drug Administration approved two drugs for the treatment of hypoactive sexual desire disorder in premenopausal women which have been tested in preclinical tests with positive effects on some appetitive sexual behavior in female rats. Some years after their commercial release, the effectiveness of both drugs in women is not clear. In the present chapter, we present some ...
  • Disrupting the Social and Time Vacuum: A Systemic and Lifespan Perspective on Job Insecurity 

    Debus, Maike E.; Unger, Dana (Journal article; Tidsskriftartikkel, 2023)
    In their lead article, Klug et al. conceptualize job insecurity as a multilevel construct whereby individuals are situated in meso- and macro-level contexts. Their resulting model highlights that the experience of job insecurity, as well as reactions to job insecurity, are not only affected by factors emanating from individuals' direct environment (i.e., at the individual level) but also from different ...
  • Evaluation of Sexual Behavior in Laboratory vs Seminatural Conditions 

    Chu, Xi; Ågmo, Anders j (Chapter; Bokkapittel, 2023-05-17)
    Sexual behavior is, by necessity, sexually dimorphic. Males transfer sperm to females, whereas females receive sperm from males. Discussions of sex differences in copulatory behavior are consequently trivial. However, the behaviors associated with copulation, for example mate choice or postcopulatory reactions, may well be similar in males and females. Such differences, even subtle, are far easier ...
  • Changes in reward-induced neural activity upon Cafeteria Diet consumption 

    Heijkoop, Roy; Ferrer Lalanza, Jaume; Solanas, Montserrat; Álvarez-Monell, Adam; Subias-Gusils, Alex; Escorihuela, Rosa; Snoeren, Eelke Mirthe Simone (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-01)
    Excessive consumption of highly palatable foods rich in sugar and fat, often referred to as “junk” or “fast” foods, plays a central role in the development of obesity. The highly palatable characteristics of these foods activate hedonic and motivational mechanisms to promote food-seeking behavior and overeating, which is largely regulated by the brain reward system. Excessive junk food consumption ...
  • From serial reproduction to serial communication: transmission of the focus of comparison in lay communication about gender inequality 

    Braun, Maike; Martiny, Sarah E.; Bruckmüller, Susanne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-21)
    We introduce and explore the potential of the serial communication method, a modification of the serial reproduction paradigm in which participants communicate their own thoughts. It affords participants more agency, more closely simulating real communication. We specifically examined the transmission of the focus of comparison in explanations of gender inequality, a consequential form of equivalency ...
  • Kunnskapsoppsummering og klassifisering av tiltaket: Flyt 

    Sagatun, Åse; Sæle, Rannveig Grøm (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-12)
    Bakgrunn: Flyt er et livsmestringsprogram for elever på 10. trinn som har til hensikt å gjøre deltakere bedre rustet til å gjennomføre videregående skole. Programmet er et styrkebasert gruppetiltak for ungdom i risiko for å droppe ut fra videregående, men ungdom uten kjent risiko inkluderes også. For elever omfatter tiltaket totalt 80 timer med organiserte aktiviteter fordelt på helg- og kveldssamlinger ...
  • Echoes from Intrinsic Connectivity Networks in the Subcortex 

    Groot, Josephine Maria; Miletic, Steven; Isherwood, Scott J.S.; Tse, Desmond H.Y.; Habli, Sarah; Håberg, Asta; Forstmann, Birte U.; Bazin, Pierre-Louis; Mittner, Matthias Bodo (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-27)
    Decades of research have greatly improved our understanding of intrinsic human brain organization in terms of functional networks and the transmodal hubs within the cortex at which they converge. However, substrates of multinetwork integration in the human subcortex are relatively uncharted. Here, we leveraged recent advances in subcortical atlasing and ultra-high field (7 T) imaging optimized for ...
  • Sexual Incentive Motivation 

    Huijgens, Patty; Heijkoop, Roy; Snoeren, Eelke (Chapter; Bokkapittel, 2023-05-17)
    Motivation can be described as the processes that activate, direct, and determine the persistence of goal-directed behavior. A certain level of sexual motivation is required to activate approach behavior which could potentially lead to copulation and reproduction. Here, we discuss the use of the sexual incentive motivation test to assess the magnitude of sexual motivation in rodents in response to ...
  • Impact of active placebo controls on estimated drug effects in randomised trials: a systematic review of trials with both active placebo and standard placebo 

    Laursen, David RT; Nejstgaard, Camilla Hansen; Bjørkedal, Espen; Dreyer Frost, Anders; Rix Hansen, Morten; Paludan-Müller, Asger S; Prosenz, Julian; Werner, Christoph Patrick; Hrjóbjartsson, Asbjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-06)
    Background - An estimated 60% of pharmacological randomised trials use placebo control interventions to blind (i.e. mask) participants. However, standard placebos do not control for perceptible non‐therapeutic effects (i.e. side effects) of the experimental drug, which may unblind participants. Trials rarely use active placebo controls, which contain pharmacological compounds designed to mimic the ...
  • Echoes from Intrinsic Connectivity Networks in the Subcortex 

    Miletic, Steven; Isherwood, Scott J.S.; Tse, Desmond H.Y.; Habli, Sarah; Håberg, Asta Kristine; Forstmann, Birte U.; Bazin, Pierre-Louis; Mittner, Matthias Bodo; Groot, Josephine M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-27)
    Decades of research have greatly improved our understanding of intrinsic human brain organization in terms of functional networks and the transmodal hubs within the cortex at which they converge. However, substrates of multinetwork integration in the human subcortex are relatively uncharted. Here, we leveraged recent advances in subcortical atlasing and ultra-high field (7 T) imaging optimized for ...
  • The elusive concept of sexual motivation: can it be anchored in the nervous system? 

    Ventura-Aquino, Elisa; Ågmo, Anders j (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-17)
    Sexual motivation is an abstract concept referring to the mechanisms determining the responsivity to sexually relevant stimuli. This responsivity determines the likelihood of producing a sexual response and the intensity of that response. Both responsivity to stimuli and the likelihood of making a response as well as the intensity of response are characteristics of an individual. Therefore, we need ...
  • Kunnskapsoppsummering og klassifisering av tiltaket: Cool Kids (1. utg.) 

    Kaasbøll, Jannike; Brøndbo, Per Håkan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-09)
    Bakgrunn: Denne artikkelen er en kunnskapsoppsummering og klassifisering av tiltaket Cool Kids, et program med hovedmålsetting å hjelpe barn og unge i alderen 6-18 år å håndtere angst og relaterte vansker. Programmet kan tilbys både individuelt og i gruppeformat, med ca. 10 møter. Cool Kids -programmet er teoretisk forankret i kognitiv adferdsterapi. Sentrale metoder i programmet omfatter psykoedukasjon, ...
  • Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults 

    Hemminghyth, Mathilde Suhr; Chwiszczuk, Luiza; Breitve, Monica Haraldseid; Gisladottir, Berglind; Grøntvedt, Gøril Rolfseng; Nakling, Arne Exner; Rongve, Arvid; Fladby, Tormod; Kirsebom, Bjørn-Eivind Seljelid (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-27)
    Multiple cognitive domains, including learning, memory, and psychomotor speed, show significant reductions with age. Likewise, several cerebrospinal fluid (CSF) neurodegenerative biomarkers, including total tau (t-tau, a marker of neuronal body injury) and neurofilament light chain (NfL, a marker of axonal injury) show age-related increases in normal aging. In the current study, we aimed to investigate ...
  • Risk factors for sexual harassment and abuse victimization among adolescent athletes and non-athletes: A one-year follow-up study 

    Sølvberg, Nina; Torstveit, Monica Klungland; Solstad, Bård Erlend; Mountjoy, Margo; Rosenvinge, Jan Harald; Pettersen, Gunn; Sundgot-Borgen, Jorunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-18)
    Background: The association between SHA and negative mental health increases the need to understand risk factors for SHA victimization, which is important for future development of prevention programs.<p> <p>Objective: To examine which combinations of demographic- and mental health factors were associated with subsequent SHA victimization, and the prevalence of elite athletes, recreational athletes, ...
  • Post-traumatic stress disorder among heart disease patients: a clinical follow-up of individuals with myocardial infarction in the Tromsø Study 

    Lorem, Geir Fagerjord; Næss, Eva Therese; Løchen, Maja-Lisa; Lillevoll, Kjersti Rønningen; Molund, Else-Marie; Rösner, Assami; Lindkvist, Sigmund; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-12)
    Background Myocardial infarction is likely to be experienced as a life-threatening and potentially traumatic event. Approximately one-third of patients with myocardial infarction experience clinically significant symptoms of anxiety/ depression. However, it is unclear how many of these patients experience these symptoms because of post-traumatic stress disorder (PTSD). We conducted a clinical screening ...
  • Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease 

    Nordengen, Kaja; Kirsebom, Bjørn-Eivind Seljelid; Richter, Grit; Pålhaugen, Lene; Gisladottir, Berglind; Siafarikas, Nikias Ioannis; Nakling, Arne Exner; Rongve, Arvid; Bråthen, Geir; Grøntvedt, Gøril Rolfseng; Gonzalez, Fernando; Waterloo, Knut; Sharma, Kulbhushan; Karikari, Thomas; Vromen, Eleonora M.; Tijms, Betty M.; Visser, Pieter J.; Selnes, Per; Kramberger, Milicia G.; Winblad, Bengt; Blennow, Kaj; Fladby, Tormod (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-13)
    Background - Brain innate immune activation is associated with Alzheimer’s disease (AD), but degrees of activation may vary between disease stages. Thus, brain innate immune activation must be assessed in longitudinal clinical studies that include biomarker negative healthy controls and cases with established AD pathology. Here, we employ longitudinally sampled cerebrospinal fluid (CSF) core AD, ...

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