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dc.contributor.authorBrunvoll, Sonja Hjellegjerde
dc.contributor.authorThune, Inger
dc.contributor.authorFrydenberg, Hanne
dc.contributor.authorFlote, Vidar Gordon
dc.contributor.authorBertheussen, Gro Falkener
dc.contributor.authorSchlichting, Ellen
dc.contributor.authorBjerve, Kristian S
dc.contributor.authorHjartåker, Anette
dc.date.accessioned2018-12-07T10:54:37Z
dc.date.available2018-12-07T10:54:37Z
dc.date.issued2018
dc.description.abstract<p><i>Background</i>: The role of n-3 polyunsaturated fatty acids (PUFAs) in breast cancer is not clear and under debate. To explore this relationship it is important to have proper validated dietary assessment methods for measuring the intake of n-3 PUFAs. The aim of the current study is to validate two different methods used to assess the intake of selected n-3 PUFAs as well as food sources of long-chained n-3 PUFAs. Also, we aim to study how stable the intake of fatty acids is during breast cancer treatment.</p> <p><i>Methods</i>: The study-population was patients with breast cancer (Stages I-II) or ductal carcinoma in situ (DCIS-grade III) undergoing treatment (n = 49) in Norway. Dietary intake was assessed by two self-administered methods, a 256 food item food frequency questionnaire (FFQ) and a 7-day pre-coded food diary (PFD). The FFQ was administered presurgery and twelve months postsurgery, and the PFD was administered shortly after surgery (10 +/− 2 days), six and twelve months postsurgery. Fasting blood samples (presurgery, six and twelve months postsurgery) were analysed for serum phospholipid fatty acids, a biomarker for intake of n-3 PUFAs.</p> <p><i>Results</i>: Mean (SD) age was 54.2 (7.8) years at diagnosis, and the mean (SD) body mass index (BMI) was 24.8 (3.4) kg/m2. Correlation coefficients between dietary intakes of n-3 PUFAs measured with the FFQ and the PFD ranged from 0.35 to 0.66. The correlation coefficients between the PFD and the biomarker (serum phospholipid n-3 PUFAs) as well as between the FFQ and the biomarker demonstrated stronger correlations twelve months after surgery (ρ 0.40–0.56 and 0.36–0.53, respectively) compared to around surgery (ρ 0.08–0.20 and 0.28–0.38, respectively). The same pattern was observed for intake of fatty fish. The intake of n-3 PUFAs did not change during treatment assessed by the FFQ, PFD or biomarker.</p> <p><i>Conclusion</i>: These results indicate that the FFQ and the PFD can be used to assess dietary intake of fish and n-3 PUFAs in breast cancer patients during breast cancer treatment. Still, the PFD shortly after surgery should be used with caution. The diet of patients undergoing breast cancer treatment was quite stable, and the intake of n-3 PUFAs did not change.en_US
dc.description.sponsorshipInstitute of Basic Medical Sciences, University of Oslo The Throne Holst Nutrition Research Foundation South-East Norwegian Health Authority Active Against Cancer Gjensidige Stiftelsenen_US
dc.descriptionSource at <a href=https://doi.org/10.1186/s12937-018-0402-6> https://doi.org/10.1186/s12937-018-0402-6</a>. Licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a>en_US
dc.identifier.citationBrunvoll, S.H., Thune, I., Frydenberg, H., Flote, V.G., Bertheussen, G.F., Schlichting, E., ... Hjartåker, A. (2018). Validation of repeated self-reported n-3 PUFA intake using serum phospholipid fatty acids as a biomarker in breast cancer patients during treatment 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis. <i>Nutrition Journal</i>, 17(94). https://doi.org/10.1186/s12937-018-0402-6en_US
dc.identifier.cristinIDFRIDAID 1630483
dc.identifier.doi10.1186/s12937-018-0402-6
dc.identifier.issn1475-2891
dc.identifier.urihttps://hdl.handle.net/10037/14299
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalNutrition Journal
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/KLINISK/213997/Norway/Insulin, lipids and Breast Cancer in a Randomised Clinical Trial. The Energy and Balance Aspects studies (EBBA I +II)//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811en_US
dc.subjectSerum phospholipid fatty acidsen_US
dc.subjectbiomarkeren_US
dc.subjectFood frequency questionnaireen_US
dc.subjectPre-coded food diaryen_US
dc.subjectN-3 PUFAsen_US
dc.subjectFishen_US
dc.subjectValidationen_US
dc.subjectBreast canceren_US
dc.titleValidation of repeated self-reported n-3 PUFA intake using serum phospholipid fatty acids as a biomarker in breast cancer patients during treatment 11 Medical and Health Sciences 1112 Oncology and Carcinogenesisen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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