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dc.contributor.authorHansen, Synne Simonsen
dc.contributor.authorAasum, Ellen
dc.contributor.authorHafstad, Anne Dragøy
dc.date.accessioned2019-01-11T14:18:05Z
dc.date.available2019-01-11T14:18:05Z
dc.date.issued2017-07-25
dc.description.abstractSystemic changes during diabetes such as high glucose, dyslipidemia, hormonal changes and low grade inflammation, are believed to induce structural and functional changes in the cardiomyocyte associated with the development of diabetic cardiomyopathy. One of the hallmarks of the diabetic heart is increased oxidative stress. NADPH-oxidases (NOXs) are important ROS-producing enzymes in the cardiomyocyte mediating both adaptive and maladaptive changes in the heart. NOXs have been suggested as a therapeutic target for several diabetic complications, but their role in diabetic cardiomyopathy is far from elucidated. In this review we aim to provide an overview of the current knowledge regarding the understanding of how NOXs influences cardiac adaptive and maladaptive processes in a “diabetic milieu”. This article is part of a Special issue entitled Cardiac adaptations to obesity, diabetes and insulin resistance, edited by Professors Jan F.C. Glatz, Jason R.B. Dyck and Christine Des Rosiers.en_US
dc.description.sponsorshipNovo Nordisk Foundation The Norwegian Health Association UiT The Arctic University of Norwayen_US
dc.descriptionSubmitted manuscript version. Published version available at <a href=https://doi.org/10.1016/j.bbadis.2017.07.025> https://doi.org/10.1016/j.bbadis.2017.07.025</a>.en_US
dc.identifier.citationHansen, S.S., Aasum, E. & Hafstad, A.D. (2018). The role of NADPH oxidases in diabetic cardiomyopathy. <i>Biochimica et Biophysica Acta - Molecular Basis of Disease</i>, 1864(5), 1908-1913. https://doi.org/10.1016/j.bbadis.2017.07.025en_US
dc.identifier.issn0925-4439
dc.identifier.issn1879-260X
dc.identifier.otherFRIDAID 1631693
dc.identifier.other10.1016/j.bbadis.2017.07.025
dc.identifier.urihttps://hdl.handle.net/10037/14429
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalBiochimica et Biophysica Acta - Molecular Basis of Disease
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811en_US
dc.subjectNADPH oxidasesen_US
dc.subjectDiabetic cardiomyopathyen_US
dc.subjectOxidative stressen_US
dc.subjectMetabolismen_US
dc.subjectObesity and insulin resistanceen_US
dc.titleThe role of NADPH oxidases in diabetic cardiomyopathyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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