Show simple item record

dc.contributor.authorKleveland, Ola
dc.contributor.authorUeland, Thor
dc.contributor.authorKunszt, Gabor
dc.contributor.authorBratlie, Marte
dc.contributor.authorYndestad, Arne
dc.contributor.authorBroch, Kaspar
dc.contributor.authorHolte, Espen
dc.contributor.authorRyan, Liv
dc.contributor.authorAmundsen, Brage H.
dc.contributor.authorBendz, Bjørn
dc.contributor.authorAakhus, Svend
dc.contributor.authorEspevik, Terje
dc.contributor.authorHalvorsen, Bente
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorWiseth, Rune
dc.contributor.authorGullestad, Lars
dc.contributor.authorAukrust, Pål
dc.contributor.authorDamås, Jan Kristian
dc.date.accessioned2019-01-15T10:45:15Z
dc.date.available2019-01-15T10:45:15Z
dc.date.issued2018-06-29
dc.description.abstract<p><i>Aim</i>: To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI).</p> <p><i>Methods</i>: 117 patients with acute NSTEMI were randomised to an intravenous infusion of 280 mg tocilizumab or placebo prior to coronary angiography. Blood samples were obtained at baseline, at 6 consecutive points in time during hospitalisation, and at follow-up after 3 and 6 months. Cytokines (n = 27) were analysed with a multiplex cytokine assay.</p> <p><i>Results</i>: Using a mixed between-within subjects analysis of variance, we observed a significant (p < 0.001) between-group difference in changes for interferon gamma-inducible protein (IP-10) and macrophage inflammatory protein-1β (MIP-1β), due to significant increases in the tocilizumab group during hospitalisation (i.e., IP-10 median change from baseline during hospitalisation (m<sub>Δ</sub>), placebo: 3 (−60, 68) pg/ml vs tocilizumab: 209 (69, 335) pg/ml; MIP-1β m<sub>Δ</sub>, placebo: 5 (−2, 12) pg/ml vs tocilizumab: 39 (24, 63) pg/ml). MIP-1β was inversely correlated to troponin T (r = −0.28, p < 0.05) and neutrophils (r = −0.32, p < 0.05) in the tocilizumab group. In contrast, tocilizumab had only modest or no effects on the other examined cytokines.</p> <p><i>Conclusions</i>: Tocilizumab led to a selective and substantial increase in IP-10 and MIP-1β during the acute phase of NSTEMI, with no or only minor effects on the other measured cytokines. ClinicalTrials.gov, NCT01491074.en_US
dc.description.sponsorshipSouth-Eastern Norway Regional Health Authoritiesen_US
dc.descriptionAccepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a> Published version available at <a href=https://doi.org/10.1016/j.ijcard.2018.04.136> https://doi.org/10.1016/j.ijcard.2018.04.136</a>.en_US
dc.identifier.citationKleveland, O., Ueland, T., Kunszt, G., Bratlie, M., Yndestad, A., Broch, K., ... Damås, J.K. (2018). Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction. <i>International Journal of Cardiology</i>, 271. https://doi.org/10.1016/j.ijcard.2018.04.136en_US
dc.identifier.cristinIDFRIDAID 1592316
dc.identifier.doi10.1016/j.ijcard.2018.04.136
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754
dc.identifier.urihttps://hdl.handle.net/10037/14446
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalInternational Journal of Cardiology
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectTocilizumaben_US
dc.subjectInterleukin-6en_US
dc.subjectInflammationen_US
dc.subjectMyocardial infarctionen_US
dc.subjectIP-10en_US
dc.subjectMIP-1βen_US
dc.titleInterleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarctionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record