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dc.contributor.authorFalavigna, Margherita
dc.contributor.authorSkalko-Basnet, Natasa
dc.contributor.authorCavallari, Cristina
dc.contributor.authorPini, Andrea
dc.contributor.authorLuppi, Barbara
dc.contributor.authorDi Cagno, Massimiliano Pio
dc.date.accessioned2019-01-15T10:57:39Z
dc.date.available2019-01-15T10:57:39Z
dc.date.issued2017-05-05
dc.description.abstractThe aim of this study was to prepare and optimize a novel type of in situ gel-forming solid dosage form (gfSDF) to be used in the treatment of mucosal/skin ulcerations. For this purpose, a simple but reliable syringe-based hot melt/moulding method was employed. Chloramphenicol (antibiotic) and ibuprofen (anti-inflammatory) were chosen as model active pharmaceutical ingredients (APIs) to be loaded into the gfSDFs. To optimize the formulations, the gfSDFs of different compositions were studied in terms of APIs release from the matrix, solid-state characteristics, gellification properties and gfSDFs resistance to mechanical stress. Release studies showed that both APIs were released at a constant rate at different pH (pH 5 and 7.4, respectively) and the changes in the formulation composition affected the release behaviour. Differential scanning calorimetry (DSC) results evidenced the complete solubilization of both API in the solid matrix. Texture analysis showed that the gfSDFs were capable of swelling once in a contact with aqueous environment and that the textural properties changed extemporaneously from the solid to gel form. The gel formed after hydration exhibited high cohesiveness and adhesiveness, an indication of good mucoadhesion properties. Friability testing confirmed satisfactory physical strength for a solid dosage form.en_US
dc.description.sponsorshipErasmus Plusen_US
dc.descriptionAccepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a> Published version available at <a href=https://doi.org/10.1016/j.ejps.2017.05.008> https://doi.org/10.1016/j.ejps.2017.05.008</a>.en_US
dc.identifier.citationFalavigna, M., Škalko-Basnet, N., Cavallari, C., Pini, A., Luppi, B. & Di Cagno, M. (2017). Novel in situ gel-forming solid dosage form (gfSDF) prepared by the simple syringe-based moulding: A screening study. <i>European Journal of Pharmaceutical Sciences</i>, 105, 11-18. https://doi.org/10.1016/j.ejps.2017.05.008en_US
dc.identifier.cristinIDFRIDAID 1469253
dc.identifier.doi10.1016/j.ejps.2017.05.008
dc.identifier.issn0928-0987
dc.identifier.issn1879-0720
dc.identifier.urihttps://hdl.handle.net/10037/14447
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEuropean Journal of Pharmaceutical Sciences
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.subjectChloramphenicolen_US
dc.subjectIbuprofenen_US
dc.subjectSolid dosage formen_US
dc.subjectDifferential scanning calorimetry (DSC)en_US
dc.subjectIn situ gellingen_US
dc.subjectDrug releaseen_US
dc.subjectMucoadhesionen_US
dc.titleNovel in situ gel-forming solid dosage form (gfSDF) prepared by the simple syringe-based moulding: A screening studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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