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dc.contributor.authorBerben, Philippe
dc.contributor.authorBauer-Brandl, Annette
dc.contributor.authorBrandl, Martin
dc.contributor.authorFaller, Bernard
dc.contributor.authorFlaten, Gøril Eide
dc.contributor.authorJacobsen, Ann-Cathrine
dc.contributor.authorBrouwers, Joachim
dc.contributor.authorAugustijns, Patrick
dc.date.accessioned2019-01-16T13:03:26Z
dc.date.available2019-01-16T13:03:26Z
dc.date.issued2018-04-13
dc.description.abstractCell-free permeation systems are gaining interest in drug discovery and development as tools to obtain a reliable prediction of passive intestinal absorption without the disadvantages associated with cell- or tissue-based permeability profiling. Depending on the composition of the barrier, cell-free permeation systems are classified into two classes including (i) biomimetic barriers which are constructed from (phospho)lipids and (ii) non-biomimetic barriers containing dialysis membranes. This review provides an overview of the currently available cell-free permeation systems including Parallel Artificial Membrane Permeability Assay (PAMPA), Phospholipid Vesicle-based Permeation Assay (PVPA), Permeapad®, and artificial membrane based systems (e.g. the artificial membrane insert system (AMI-system)) in terms of their barrier composition as well as their predictive capacity in relation to well-characterized intestinal permeation systems. Given the potential loss of integrity of cell-based permeation barriers in the presence of food components or pharmaceutical excipients, the superior robustness of cell-free barriers makes them suitable for the combined dissolution/permeation evaluation of formulations. While cell-free permeation systems are mostly applied for exploring intestinal absorption, they can also be used to evaluate non-oral drug delivery by adjusting the composition of the membrane.en_US
dc.descriptionSource at <a href= https://doi.org/10.1016/j.ejps.2018.04.016> https://doi.org/10.1016/j.ejps.2018.04.016 </a>.en_US
dc.identifier.citationBerben, P., Bauer-Brandl, A., Brandl, M., Faller, B., Flaten, G.E., Jacobsen, A.C.,… Augustijns, P.(2018). Drug permeability profiling using cell-free permeation tools: Overview and applications. Journal of Pharmaceutical Sciences, 119,219-233. https://doi.org/10.1016/j.ejps.2018.04.016.en_US
dc.identifier.cristinIDFRIDAID 1625357
dc.identifier.doi10.1016/j.ejps.2018.04.016
dc.identifier.issn0928-0987
dc.identifier.issn1879-0720
dc.identifier.urihttps://hdl.handle.net/10037/14461
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEuropean Journal of Pharmaceutical Sciences
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-JTI/115369/EU/Oral biopharmaceutics tools/ORBITO/.en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.subjectArtificial membrane insert system (AMI-system)en_US
dc.subjectOral drug deliveryen_US
dc.subjectParallel artificial membrane permeability assay (PAMPA)en_US
dc.subjectPermeabilityen_US
dc.subjectPermeapaden_US
dc.subjectPhospholipid vesicle-based permeation assay (PVPA)en_US
dc.titleDrug permeability profiling using cell-free permeation tools: Overview and applicationsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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