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dc.contributor.authorMyrvang, Anna Dahl
dc.contributor.authorVangberg, Torgil Riise
dc.contributor.authorStedal, Kristin
dc.contributor.authorRø, Øyvind
dc.contributor.authorEndestad, Tor
dc.contributor.authorRosenvinge, Jan H
dc.contributor.authorAslaksen, Per M
dc.date.accessioned2019-02-04T09:40:40Z
dc.date.available2019-02-04T09:40:40Z
dc.date.embargoEndDate2019-10-26
dc.date.issued2018-10-25
dc.description.abstractPatients with anorexia nervosa (AN) exhibit volume reduction in cerebral gray matter (GM), and several studies report reduced hippocampus volume. The hippocampal subfields (HS) are functionally and structurally distinct, and appear to respond differently to neuropathology. The aim of this study was to investigate HS volumes in adolescent females with restrictive AN compared to a healthy age-matched control group (HC). The FreeSurfer v6.0 package was used to extract brain volumes, and segment HS in 58 female adolescents (AN = 30, HC = 28). We investigated group differences in GM, white matter (WM), whole hippocampus and 12 HS volumes. AN patients had significantly lower total GM and total hippocampal volume. No group difference was found in WM. Volume reduction was found in 11 of the 12 HS, and most results remained significant when adjusting for global brain volume reduction. Investigations of clinical covariates revealed statistically significant relationships between the whole hippocampus, several HS and scores on depression and anxiety scales in AN. Results from this study show that young AN patients exhibit reduced volume in most subfields of the hippocampus, and that this reduction may be more extensive than the observed global cerebral volume loss.en_US
dc.descriptionAccepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a> Published version available at <a href=https://doi.org/10.1016/j.pscychresns.2018.10.007> https://doi.org/10.1016/j.pscychresns.2018.10.007</a>.en_US
dc.identifier.citationMyrvang, A.D., Vangberg, T.R., Stedal, K., Rø, Ø., Endestad, T., Rosenvinge, J.H. & Aslaksen, P.M. (2018). Hippocampal Subfields in Adolescent Anorexia Nervosa. <i>Psychiatry Research: Neuroimaging</i>, 282, 24-30. https://doi.org/10.1016/j.pscychresns.2018.10.007en_US
dc.identifier.issn0925-4927
dc.identifier.issn1872-7506
dc.identifier.otherFRIDAID 1626978
dc.identifier.other10.1016/j.pscychresns.2018.10.007
dc.identifier.urihttps://hdl.handle.net/10037/14595
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalPsychiatry Research : Neuroimaging
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BEDREHELSE/229142/Norway/COGNITIVE AND CEREBRAL CHANGES IN PATIENTS WITH ANOREXIA NERVOSA//en_US
dc.relation.urihttps://authors.elsevier.com/a/1Xzmf3IRiGjt5k
dc.rights.accessRightsembargoedAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Psychiatry, child psychiatry: 757en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Psykiatri, barnepsykiatri: 757en_US
dc.titleHippocampal Subfields in Adolescent Anorexia Nervosaen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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