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dc.contributor.authorEvensen, Line Holtet
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2019-02-05T10:41:21Z
dc.date.available2019-02-05T10:41:21Z
dc.date.issued2018-10-05
dc.description.abstractVenous thromboembolism (VTE) is a complex multifactorial disease that represents a growing public health concern. Identification of modifiable risk factors at the population level may provide a measure to reduce the burden of VTE. In this review, we summarize current knowledge of the role of physical activity on the risk of VTE and VTE-related complications. We also discuss methodological challenges related to research on physical activity, and put forward plausible mechanisms for an association between physical activity and VTE. Up to now, published studies have reported diverging results on the relationship between physical activity and VTE, and a complex picture has emerged. However, the available evidence appears to be balanced toward a small beneficial effect of physical activity on the risk of incident VTE, but not in a dose-dependent manner. Still, the lack of an operational definition and standardized assessment method for physical activity, as well as several sources of bias, impairs the interpretation of the available literature. Additional work is necessary to understand the role and how to apply physical activity in the VTE setting. Future research should utilize objective assessment strategies of physical activity and physical fitness, account for the fluctuating nature in habitual activity levels, and explore the role of physical activity in the areas of secondary prevention and VTE-related complications.en_US
dc.description.sponsorshipStiftelsen Kristian Gerhard Jebsenen_US
dc.descriptionAccepted manuscript version. Published version available at <a href=https://doi.org/10.1055/s-0038-1673636> https://doi.org/10.1055/s-0038-1673636</a>.en_US
dc.identifier.citationEvensen, L.H., Brækkan, S.K. & Hansen, J.-B. (2018). Regular physical activity and risk of venous thromboembolism. <i>Seminars in Thrombosis and Hemostasis, 44</i>(8), 765-779. https://doi.org/10.1055/s-0038-1673636en_US
dc.identifier.cristinIDFRIDAID 1641351
dc.identifier.doi10.1055/s-0038-1673636
dc.identifier.issn0094-6176
dc.identifier.issn1098-9064
dc.identifier.urihttps://hdl.handle.net/10037/14614
dc.language.isoengen_US
dc.publisherThieme Publishingen_US
dc.relation.ispartofFinal version of this paper is part of: <p> <p>Evensen, L.H. (2020). Physical activity, cardiorespiratory fitness and venous thromboembolism. (Doctoral thesis). <a href=https://hdl.handle.net/10037/18072>https://hdl.handle.net/10037/18072. </a>
dc.relation.journalSeminars in Thrombosis and Hemostasis
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775en_US
dc.subjectphysical activityen_US
dc.subjectrisk factoren_US
dc.subjectvenous thromboembolismen_US
dc.subjectreviewen_US
dc.titleRegular physical activity and risk of venous thromboembolismen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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