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dc.contributor.authorStylidis, Michael
dc.contributor.authorSharashova, Ekaterina
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorLeon, David A.
dc.contributor.authorHeggelund, Geir
dc.contributor.authorRøsner, Assami
dc.contributor.authorNjølstad, Inger
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorSchirmer, Henrik
dc.date.accessioned2019-02-06T08:20:01Z
dc.date.available2019-02-06T08:20:01Z
dc.date.issued2019-01-28
dc.description.abstract<p><i>Aims</i>: To examine the associations between diastolic dysfunction indices and long‐term risk of all‐cause mortality in adults over 23‐year follow‐up.</p> <p><i>Methods and results</i>: Participants (n = 2734) of the population‐based Tromsø Study of Norway had echocardiography in 1994–1995. Of these 67% were repeated in 2001 and/or 2007–2008. Mortality between 1994 and 2016 was determined by linkage to the national death registry. Cox regression was used to model the hazard of all‐cause mortality in relation to left atrial parameters (treated as time‐dependent using repeated measurements) adjusted for traditional risk factors and cardiovascular disease. During the follow‐up, 1399 participants died. Indexed left atrial diameter, mitral peak E deceleration time, and mitral peak E to peak A ratio showed an U‐shaped association with all‐cause mortality. Combining left atrial diameter with mitral peak E deceleration time increased the prognostic accuracy for all‐cause mortality whereas adding mitral peak E to peak A ratio did not increase prognostic value. We estimated new optimal cutoff values of left atrial diameter, mitral peak E deceleration time, and mitral peak E to peak A ratio for all‐cause mortality outcome. E/e′ had a cubic relation to mortality.</p> <p><i>Conclusion</i>: Both enlarged and small left atrial diameters were associated with increased all‐cause mortality risk. A combination of Doppler‐based left ventricle filling parameters had an incremental effect on all‐cause mortality risk. The cutoff values of diastolic dysfunction indices we determined had similar all‐cause mortality prediction ability as those recommended by American Association of Echocardiography and European Association of Cardiovascular Imaging.</p>en_US
dc.description.sponsorshipUiT The Arctic University of Norway International Project on Cardiovascular Disease in Russia London School of Hygiene and Tropical Medicine Simon Fougner Hartman’s Family Foundationen_US
dc.descriptionThis is the peer reviewed version of the following article: Stylidis, S., Sharashova, E., Wilsgaard, T., Leon, D.A., Heggelund, G., Rösner, A, ... Schirmer, H. (2019). Left atrial diameter, left ventricle filling indices, and association with all-cause mortality: Results from the population-based Tromsø Study. <i>Echocardiography</i>, which has been published in final form at <a href=https://doi.org/10.1111/echo.14270> https://doi.org/10.1111/echo.14270</a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.identifier.citationStylidis, S., Sharashova, E., Wilsgaard, T., Leon, D.A., Heggelund, G., Rösner, A, ... Schirmer, H. (2019). Left atrial diameter, left ventricle filling indices, and association with all-cause mortality: Results from the population-based Tromsø Study. <i>Echocardiography</i>. https://doi.org/10.1111/echo.14270en_US
dc.identifier.cristinIDFRIDAID 1669758
dc.identifier.doi10.1111/echo.14270
dc.identifier.issn0742-2822
dc.identifier.issn1540-8175
dc.identifier.urihttps://hdl.handle.net/10037/14624
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.ispartofStylidis, M. (2020). Clinical characteristics, echocardiographic indices of heart failure and mortality in a general population. The Tromsø Study. (Doctoral thesis). <a href=https://hdl.handle.net/10037/18928>https://hdl.handle.net/10037/18928</a>.
dc.relation.journalEchocardiography
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectall‐cause mortalityen_US
dc.subjectdiastolic dysfunctionen_US
dc.subjectechocardiographyen_US
dc.subjectepidemiologyen_US
dc.subjectleft atrial diameteren_US
dc.subjectprognosisen_US
dc.titleLeft atrial diameter, left ventricle filling indices, and association with all-cause mortality: Results from the population-based Tromsø Study.en_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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